Seizure threshold

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The term seizure threshold is used to describe the balance between excitatory and inhibitory forces in the brain which affect how susceptible a person is to seizures. Those diagnosed with epilepsy or certain other neurological conditions are vulnerable to sudden new seizures if the threshold is upset, and so must be especially careful and compliant with their therapeutic drug regimen if they must use anticonvulsants.

Drugs such as the antidepressant and nicotinic antagonist bupropion (Wellbutrin, Zyban) and the opioid analgesics Tramadol (Ultram, Ultram ER, Ultracet) and tapentadol (Nucynta, Palexia, TAPAL) can lower the seizure threshold. So can other factors, including:

  • exposure to neon lights, laser lights and even flashing lights
  • lengthy periods of fasting, malnutrition, starvation, lengthy periods of high stress and/or fear, fatigue and exhaustion
  • uncontrolled diabetes, and
  • other endocrine and metabolic irregularities (like electrolyte or hormonal imbalances).

Cancer and certain disorders of the nervous, cardiovascular and gastrointestinal systems can also influence the severity and frequency of seizures.[1]

See also[edit]


  1. ^ "Seizure Mechanisms and Threshold". Epilepsy Foundation. Retrieved 2008-03-19.