Sekine Station (関根駅 Sekine-eki) is a railway station on the Ōu Main Line in the city of Yonezawa, Yamagata, Yamagata Prefecture, Japan, operated by East Japan Railway Company (JR East).
Sekine Station is served by the Ōu Main Line, and is located 34.8 rail kilometers from the terminus of the line at Fukushima Station.
Sekine Station has two opposed side platforms connected via a level crossing. The station is unattended.
Sekine Station opened on 15 May 1899. The station was absorbed into the JR East network upon the privatization of JNR on 1 April 1987.