|Jmol-3D images||Image 1|
|Molar mass||143.09 g/mol|
|Appearance||orange to brown powder|
|Solubility in water||negligible|
|Solubility||soluble in ammonium monosulfide
negligible in organic solvents
|EU classification||Toxic (T)
Dangerous for the environment (N)
|R-phrases||R23/25, R33, R50/53|
|S-phrases||(S1/2), S20/21, S28, S45, S60, S61|
|Other anions||Selenium dioxide
|Other cations||Hydrogen sulfide|
| (what is: / ?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Selenium disulfide is an inorganic compound with the approximate formula SeS2. Both sulfur and selenium catenate (form chains and rings) readily, and mixtures of selenium and sulfur likewise give rise to numerous "alloys". This compound is not an analogue of sulfur dioxide.
Medicinal selenium disulfide
The material commercially called selenium disulfide is sold as an antifungal agent in shampoos for the treatment of dandruff and seborrheic dermatitis associated in the scalp with Malassezia genus fungi. In the United States, a 1% strength is available over-the-counter, and a 2.5% strength is also available with a prescription. At the 2.5% strength, selenium disulfide is also used on the body to treat tinea versicolor, a type of fungal skin infection caused by a different species of Malassezia.
Selenium disulfide has a composition that approximates to SeS2 and is sometimes called selenium sulfide. However, as used in proprietary formulations, it is not a pure chemical compound but is a mixture where the overall Se:S ratio is 1:2. The compounds are cyclic Se–S rings containing a variable number of S and Se atoms, SenS8−n. Selenium disulfide can cause discoloration of the hair and alter the color of hair dyes. It may also discolor metallic jewellery.
Other selenium sulfides
Many selenium sulfides are known. A useful means for characterization is 77Se NMR spectroscopy. Chalcogen ring interconversion pathways. Selenium monosulfide (SeS) is the only selenium compound so far identified as a carcinogen in animals. Selenium monosulfide, along with elemental selenium and sulfur, has been used in medicinal preparations in the past, causing confusion and contradiction as to exactly what form selenium is in in any given topical preparation.
- Zinc pyrithione, an antimicrobial agent used in some medicated shampoos.
- Selsun Blue, a shampoo with selenium disulfide as its active ingredient.
- Ketoconazole, another antifungal agent used in shampoos.
- Cyclic selenium sulfides R. Steudel, R. Laitinen, Topics in Current Chemistry, (1982), 102, 177-197
- Selenium(IV) sulfide - pharmacy codes search engine
- Chemicals of Selenium .Se
- Accessed Dec. 24, 2007
- Pekonen, Pentti.; Hiltunen, Yrjō; Laitinen, Risto S.; Pakkanen, Tapani A. (1991). "Chalcogen ring interconversion pathways. 77Se NMR spectroscopic study of the decomposition of 1,2,3,4,5-Se5S2 to 1,2,3,4,5,6-Se6S2 and 1,2,3,4-Se4S2". Inorganic Chemistry 30 (19): 3679. doi:10.1021/ic00019a022.
- "selenium compounds".
- "Definition: selenium sulfide from Online Medical Dictionary".
- "DrugBank: DB00971 (Selenium Sulfide)".
- "selenium sulfide: Definition and Much More from Answers.com".
- Danby, FW; Maddin, WS; Margesson, LJ; Rosenthal, D (December 1993). "A randomized, double-blind, placebo-controlled trial of ketoconazole 2% shampoo versus selenium sulfide 2.5% shampoo in the treatment of moderate to severe dandruff". Journal of the American Academy of Dermatology 29 (6): 1008–12. PMID 8245236.
- Grover, R. W. (1956). "Diffuse Hair Loss Associated with Selenium (Selsun) Sulfide Shampoo". JAMA: the Journal of the American Medical Association 160 (16): 1397. doi:10.1001/jama.1956.02960510023006.
- Givens, T. G.; Murray, M. M.; Baker, R. C. (1995). "Comparison of 1% and 2.5% Selenium Sulfide in the Treatment of Tinea Capitis". Archives of Pediatrics and Adolescent Medicine 149 (7): 808–11. doi:10.1001/archpedi.1995.02170200098016. PMID 7795774.
- Ransone, James W.; Scott, Norman M.; Knoblock, Edward C. (1961). "Selenium Sulfide Intoxication". New England Journal of Medicine 264 (8): 384. doi:10.1056/NEJM196102232640806.
- Laitinen, Risto S.; Pakkanen, Tapani A. (1987). "77Se NMR spectroscopic characterization of selenium sulfide ring molecules SenS8-n". Inorganic Chemistry 26 (16): 2598. doi:10.1021/ic00263a010.