The Selkirk First Nation is a First Nation band government in central Yukon, Canada. Its original population centre was the trading post of Selkirk, Yukon along the Yukon River, but most of its citizens now live in Pelly Crossing, Yukon where the Klondike Highway crosses the Pelly River. The language originally spoken by the Selkirk people was Northern Tutchone. There is a great effort to preserve the language and culture, as can be seen by the popularity of the Selkirk "Keeper of the Songs", Jerry Alfred.
The Selkirk First Nation signed a Yukon Land Claims agreement in 1997.