Semorphone
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| Systematic (IUPAC) name | |
| (5α)-4,5-Epoxy-3,14-dihydroxy-17-(2-methoxyethyl)morphinan-6-one | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 88939-40-6 |
| ATC code | None |
| PubChem | CID 5491906 |
| ChemSpider | 4590760  |
| UNII | 2HD55617I2 |
| Chemical data | |
| Formula | C19H23NO5 |
| Mol. mass | 345.39 g/mol |
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Semorphone (Mr 2264) is an opiate analogue that is an N-substituted derivative of oxymorphone.
Semorphone is a partial agonist at μ-opioid receptors. It is around twice the potency of morphine, but with a ceiling effect on both analgesia and respiratory depression[1] which means that these effects stop becoming any stronger after a certain maximum dose.
It is not currently used in medicine, and is not a controlled drug, although it might be considered to be a controlled substance analogue of oxymorphone on the grounds of its related chemical structure in some jurisdictions such as the USA, Canada, Australia and New Zealand.
References [edit]
- ^ Behne M, Bremerich D, Heinrich J, Schumacher H, Scherer M. Respiratory effects and tolerability of Mr 2264 Cl. A new opiate partial agonist in comparison with morphine and placebo. European Journal of Clinical Pharmacology. 1994;46(4):301-4.
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