The Piro Pueblo of Senecú was the southernmost occupied pueblo in New Mexico prior to the Pueblo Revolt of 1680. It was located on the west bank of the Rio Grande within sight of San Pasqual. It may have also been within the proximity of the Black Mesa, which is near San Marcial. However, the actual site location is unknown.
The original name of the pueblo has been transcribed as either Tze-no-que, Tzen-o-cue, or She-an-ghua. This has been translated as either "eye socket" or "spring hole"
The pueblo was occupied by Piro Indians prior to Spanish exploration of the area. It appears to have been described by Spaniards as early as 1581 in the journals of the Chamuscado and Rodriguez Expedition. In 1598, the Juan de Oñate expedition described a "Tzenaquel de la Mesilla", which was the first settlement that they came across while traveling through New Mexico.
The Spanish mission of San Antonio de Padua was built in Senecú in the 1620s. The mission survived for about half a century, but both the pueblo and the mission were destroyed by Apache raiders on 23 January 1675. A Franciscan priest was killed during the raid, however many Piro and Spaniards survived.
The pueblo was resettled in November or December 1677 by reportedly over 100 Christian Indian families. It was once again abandoned during the Pueblo Revolt of 1680 when the Piro followed the Spaniards out of New Mexico. Rather than return to New Mexico, the people of this pueblo settled in the El Paso district in a village called Senecú del Sur. Rumors have it that some Piro stayed in New Mexico, however Diego de Vargas did not find anyone inhabiting the pueblo when he passed by it in 1691 and 1692. The pueblo was not resettled after the Spanish re-conquest. The pueblo's ruins were visible to travelers throughout the 18th century, but they have not been seen since then.
- Julyan, Robert, (1998) "Luis Lopez" The Place Names of New Mexico (revised edition) University of New Mexico Press, Albuquerque, p. 214, ISBN 0-8263-1689-1
- Harrington, John P. (1909) "Notes on the Piro Language" American Anthropologist New Series, 11, (4): pp. 563-594, p.564
- Julyan, Robert (1998) "Senecu" The Place Names of New Mexico (revised edition) University of New Mexico Press, Albuquerque, p. 331, ISBN 0-8263-1689-1.
- Marshall, Michael P. and Walt, Henry J., (1984) "Chapter 11: Pre-Revolt Place Names: Senecú" Rio Abajo: Prehistory and History of a Rio Grande Province New Mexico Historic Preservation Division, Santa Fe, pp. 252–254, OCLC 11553460