Sepino is a comune (municipality) in the Province of Campobasso in the Italian region Molise, located about 20 kilometres (12 mi) south of Campobasso.
The archaeological site of Saepinum is located nearby. Sepino borders the following municipalities: Cercemaggiore, Cercepiccola, Guardiaregia, Morcone, Pietraroja, San Giuliano del Sannio, Sassinoro.
In the early 7th century AD, what are today the communes of Sepino, Isernia and Bojano were the places where Grimoald I of Benevento settled a group of Bulgars, seeking refuge from the Avars; the Bulgars were for many generations a distinctive part of the population, until finally assimilated in their Italian environment (see Bulgarians in Italy, Old Great Bulgaria#Bulgars in Southern Italy).
- ^ All demographics and other statistics: Italian statistical institute Istat.