|Full name||Sergio Alejandro Santana Piedra|
|Date of birth||August 10, 1979|
|Place of birth||Progreso Rio Grande,
|Height||1.80 m (5 ft 11 in)|
|* Senior club appearances and goals counted for the domestic league only and correct as of 12 May 2013.
† Appearances (Goals).
Santana first match in the Primera División de México was with C.F. Pachuca on May 7, 2000, against Toluca. He played with C.F. Pachuca for almost five years, from 2000–2005. He was transferred to Chivas de Guadalajara for the Clausura 2006 Tournament at the end of 2005. Sergio is a versatile player for Chivas, playing as a forward, striker, center attacking midfielder, and even as a defensive midfielder on occasions.
Santana represented the Mexican national team in a game against China on April 16, 2008, making his 7th appearance since Ricardo LaVolpe called him for El Tri. Recently,[when?] Santana has stated his desire to leave Chivas following the arrival of Carlos Ochoa.
On June 17, 2009, during the Mexican Football Draft in Cancun, the Monterrey announced that Santana was to join their squad. With Monterrey, he won a couple of championships and a Concacaf Champions League in 2010.
Santana's latest Mexican club is Club Atlas. He had a poor performance, as did the entire squad, in the Clausura 2012.
|1.||October 6, 2004||Estadio Hidalgo, Pachuca, Mexico||Saint Vincent and the Grenadines||7–0||7–0||2006 FIFA World Cup qualification – CONCACAF Third Round|
|2.||November 13, 2004||Miami Orange Bowl, Miami, United States||Saint Kitts and Nevis||5–0||5–0||2006 FIFA World Cup qualification – CONCACAF Third Round|
|3.||November 13, 2004||Miami Orange Bowl, Miami, United States||Saint Kitts and Nevis||5–0||5–0||2006 FIFA World Cup qualification – CONCACAF Third Round|
|4.||November 17, 2004||Estadio Tecnológico, Monterey, Mexico||Saint Kitts and Nevis||8–0||8–0||2006 FIFA World Cup qualification – CONCACAF Third Round|
|5.||March 11, 2009||Dick's Sporting Goods Park, Commerce City, Colorado, United States||Bolivia||5–1||5–1||Friendly|
As of 11 March 2009
- Primera División de México: Apertura 2009, Apertura 2010
- CONCACAF Champions League: 2010–11
- InterLiga: 2010