Sernancelhe (Portuguese pronunciation: [sɨɾnɐ̃ˈsɐʎ(ɨ)] or [sɨɾnɐ̃ˈseʎ(ɨ)]) is a municipality in the district Viseu, Portugal. The population in 2011 was 5,671, in an area of 228.61 km².
The present mayor is José Mário Almeida Cardoso, elected by the Social Democratic Party. The municipal holiday is May 3.
The municipality is composed of 13 parishes:
- Ferreirim e Macieira
- Fonte Arcada e Escurquela
- Penso e Freixinho
- Sernancelhe e Sarzeda
- Vila da Ponte