Serostatus

From Wikipedia, the free encyclopedia
Jump to: navigation, search

Serostatus refers to the presence or absence of a serological marker in the blood. The presence of abnormal detectable levels of a specific marker within the serum is considered seropositivity, while the absence of such levels is considered seronegativity.

HIV/AIDS[edit]

The term serostatus is commonly used in HIV/AIDS prevention efforts. In recent years, social advocacy has emphasized the importance of learning one's HIV/AIDS serostatus in an effort to curtail the spread of the disease.[1]

Autoimmune disease[edit]

Researchers have investigated the effects of autoantibody serostatus on autoimmune disease presentation.[2][3][4] Study of seronegative patient populations has led to the identification of additional autoantibodies that could potentially help with diagnosis.[5][6]

See also[edit]

References[edit]

  1. ^ Janssen RS, Holtgrave DR, Valdiserri RO et al. (July 2001). "The Serostatus Approach to Fighting the HIV Epidemic: prevention strategies for infected individuals". American Journal of Public Health (American Public Health Association) 91 (7): 1019–1024. doi:10.2105/AJPH.91.7.1019. ISSN 1541-0048. PMC 1446705. PMID 11441723. 
  2. ^ Jarius S, Ruprecht K, Wildemann B et al. (January 2012). "Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: A multicentre study of 175 patients". Journal of Neuroinflammation (BioMed Central) 9 (1): 14. doi:10.1186/1742-2094-9-14. PMC 3283476. PMID 22260418. 
  3. ^ Ajeganova S, Huizinga TW (November 2014). "Rheumatoid arthritis: Seronegative and seropositive RA: alike but different?". Nature Reviews Rheumatology (Nature Publishing Group) 11 (1): 8–9. doi:10.1038/nrrheum.2014.194. ISSN 1759-4804. PMID 25403158. 
  4. ^ Balasubramanian G, Sugumar A, Smyrk TC et al. (2012). "Demystifying seronegative autoimmune pancreatitis". Pancreatology (Elsevier) 12 (4): 289–294. doi:10.1016/j.pan.2012.05.003. PMID 22898628. 
  5. ^ Somers K, Geusens P, Elewaut D et al. (February 2011). "Novel autoantibody markers for early and seronegative rheumatoid arthritis". Journal of Autoimmunity (Elsevier) 36 (1): 33–46. doi:10.1016/j.jaut.2010.10.003. ISSN 0896-8411. PMID 21071175. 
  6. ^ Pevzner A, Schoser B, Peters K et al. (August 2011). "Anti-LRP4 autoantibodies in AChR- and MuSK-antibody-negative myasthenia gravis" (PDF). Journal of Neurology (Springer-Verlag) 259 (3): 427–435. doi:10.1007/s00415-011-6194-7. ISSN 1432-1459. PMID 21814823.