Serotonin reuptake inhibitor

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This article is about serotonin reuptake inhibitors. For SSRIs, see selective serotonin reuptake inhibitor.

A serotonin reuptake inhibitor (SRI) is a type of drug that acts as a reuptake inhibitor for the neurotransmitter serotonin (5-hydroxytryptamine (5-HT)) by blocking the action of the serotonin transporter (SERT). This in turn leads to increased extracellular concentrations of serotonin and, therefore, an increase in serotonergic neurotransmission.

SRIs are not synonymous with selective serotonin reuptake inhibitors (SSRIs), as the latter term is usually used to describe the class of antidepressants of the same name, and because SRIs, unlike SSRIs, can either be selective or non-selective in their action. For example, cocaine, which non-selectively inhibits the reuptake of serotonin, norepinephrine, and dopamine, can be called an SRI but not an SSRI.

SRIs are used predominantly as antidepressants (e.g., SSRIs, SNRIs, and TCAs), though they are also commonly used in the treatment of other psychological conditions such as anxiety disorders and eating disorders. Less often, SRIs are also used to treat a variety of other medical conditions including neuropathic pain and fibromyalgia (e.g., duloxetine, milnacipran), and premature ejaculation (e.g., dapoxetine) as well as for dieting (e.g., sibutramine). Additionally, some clinically used drugs like chlorpheniramine, dextromethorphan, and methadone possess SRI properties secondarily to their primary mechanism of action(s) and this contributes to their side effect and drug interaction profiles.

List of SRIs[edit]

Many SRIs exist, including the following:






Note: Only SRIs selective for the SERT over the other monoamine transporters (MATs) are listed here. For a list of SRIs that act at multiple MATs, see the other monoamine reuptake inhibitor pages such as SNRI and SNDRI.

See also[edit]

References[edit]

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  3. ^ a b Gillman PK (October 2005). "Monoamine oxidase inhibitors, opioid analgesics and toxicity". British Journal of Anaesthesia 95 (4): 434–41. doi:10.1093/bja/aei210. PMID 16051647. 
  4. ^ Pharmaceutical compositions containing mesembrine and related compounds. U.S. Patent 6,288,104 (PDF)