Sertoli cell-only syndrome
From Wikipedia, the free encyclopedia
| Sertoli cell-only syndrome | |
|---|---|
| Classification and external resources | |
| OMIM | 305700 400042 |
| DiseasesDB | 31907 |
| eMedicine | med/2104 |
| MeSH | D054331 |
Sertoli cell-only syndrome (a.k.a. Del Castillo syndrome and germ cell aplasia [1]) is a disorder characterized by male sterility without sexual abnormality. It is the result of absent seminiferous tubules in the testes of germinal epithelium, while Sertoli cells are present.[2]
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[edit] Features
The Sertoli cell-only syndrome patients normally have normal secondary male features and have normal- or small-sized testes.
[edit] Diagnosis
Testicular biopsy would confirm the absence of spermatozoa .
[edit] Pathophysiology
[edit] Treatment
Sertoli cell only syndrome is like other non-obstructive azoospermia (NOA) cases are managed by sperm retrieval through testicular sperm extraction (mTESE), micro-surgical testicular sperm extraction (mTESE) , or testicular biopsy.[3] On retrieval of viable sperms this could be used in Intracytoplasmic Sperm injection ICSI
In 1979, Levin described germinal cell aplasia with focal spermatogenesis where a variable percentage of seminiferous tubules contain germ cells.[4] It is important to discriminate between both in view of ICSI.
[edit] References
- ^ Sertoli cell-only syndrome at eMedicine
- ^ Online Medical Dictionary.
- ^ Talas H, Yaman O, Aydos K (Sep 2007). "Outcome of repeated micro-surgical testicular sperm extraction in patients with non-obstructive azoospermia". Asian J Androl. 9 (5): 668–73. doi:. PMID 17712484.
- ^ Levin HS (September 1979). "Testicular biopsy in the study of male infertility: its current usefulness, histologic techniques, and prospects for the future". Hum. Pathol. 10 (5): 569–84. PMID 43278.
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