In blood, the serum (// or //) is the component that is neither a blood cell (serum does not contain white or red blood cells) nor a clotting factor; it is the blood plasma not including the fibrinogens. Serum includes all proteins not used in blood clotting (coagulation) and all the electrolytes, antibodies, antigens, hormones, and any exogenous substances (e.g., drugs and microorganisms).
Blood is centrifuged to remove cellular components. Anti-coagulated blood yields plasma containing fibrinogen and clotting factors. Coagulated blood (clotted blood) yields serum without fibrinogen, although some clotting factors remain.
The serum of convalescent patients successfully recovering (or already recovered) from an infectious disease can be used as a biopharmaceutical in the treatment of other people with that disease, because the antibodies generated by the successful recovery are potent fighters of the pathogen. Such convalescent serum (antiserum) is a form of immunotherapy.
Like many other mass nouns, the word serum can be pluralized when used in certain senses. To speak of multiple serum specimens from multiple people (each with a unique population of antibodies), physicians sometimes speak of sera (an irregular plural, as opposed to *serums).
- Martin, Elizabeth A., ed. (2007). Concise Medical Dictionary (7th ed.). Oxford, England: Oxford University Press. ISBN 0-19-280697-1. Retrieved 8 September 2009.
- Wang, Wendy; Srivastava, Sudhir (2002). "Serological Markers". In Lester Breslow. Encyclopedia of Public Health 4. New York, New York: Macmillan Reference USA. pp. 1088–1090.
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