Setastine

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Setastine
Setastine.png
Systematic (IUPAC) name
1-[2-[1-(4-chlorophenyl)-1-phenyl-ethoxy]ethyl]azepane
Clinical data
Legal status ?
Identifiers
CAS number 59767-13-4
ATC code ?
PubChem CID 43082
ChemSpider 39258
UNII 6G3OCF528J YesY
Chemical data
Formula C22H28ClNO 
Mol. mass 357.92 g/mol

Setastine (Loderix) is an antihistamine used to treat allergies and rhinitis.[1][2]

Pharmacology[edit]

Pharmacodynamics[edit]

Setastine acts as a highly selective H1 receptor antagonist.[3] It has no anticholinergic, antiadrenergic, or antiserotonergic effects.

Pharmacokinetics[edit]

Setastine penetrates the blood-brain-barrier only weakly, hence, it is not sedating or is only mildly so.[3]

See also[edit]

References[edit]

  1. ^ Lantos A, Tóth A, Zsiray M (1991). "Loderix (setastine) tablets in the treatment of allergic rhinoconjunctivitis". Therapia Hungarica (English Edition) 39 (1): 22–4. PMID 1677500. 
  2. ^ Hirschberg A, Ribári O, Krasznai M (1989). "Results obtained with Loderix tablet in chronic rhinitis patients". Therapia Hungarica (English Edition) 37 (4): 202–4. PMID 2576575. 
  3. ^ a b Porszász J, Varga F, Porszász KG, et al. (December 1990). "Pharmacology of the new H1-receptor antagonist setastine hydrochloride". Arzneimittel-Forschung 40 (12): 1340–5. PMID 1982751.