July 26, 1813
Orange County, Virginia
|Died||December 20, 1848
St. Louis, Missouri
|Cause of death||cholera|
|Resting place||Bellefontaine Cemetery, St. Louis, Missouri|
|Citizenship||United States of America|
|Alma mater||University of Pennsylvania|
|Political party||Democratic Party|
|Parents||Philip Pendleton Barbour
Frances Todd Johnson
|Relatives||nephew of James Barbour, first cousin once removed of John S. Barbour, second cousin of John S. Barbour, Jr.|
Dr. Sextus Barbour (July 26, 1813 – December 20, 1848) was a prominent American physician and planter. As the son of Philip Pendleton Barbour (May 25, 1783 – February 25, 1841), U.S. Congressman from Virginia and Associate Justice of the United States Supreme Court, Barbour was a scion of the Barbour political family. Barbour was a nephew of James Barbour, Governor of Virginia, and a first cousin once removed of John S. Barbour, Member of the U.S. House of Representatives from Virginia's 15th congressional district.
Early life and education 
In notes in the third person, the address, and date, are to be placed, on the right side just below the last line. Both letters, and notes, are to be addressed, to the persons for whom they are intended, on the left side, of the lower part of the paper. The place of abode of the person to whom sent, to be first. This is the case when they are in the third person. The letter, or note should never be carried so, near the bottom, as not to have room for the usual conclusion, and signature or to crunch it. Postscripts should if possible be avoided, and, on no account should civilities be postponed to this part. All letters should be enveloped but such as are sent by the post. Nothing should be written when [?] the inside of the envelope; not must any address, be put on the enclosed letter. A half sheet to be used for the envelope.
A hiring agreement in 1846 between Barbour and his eldest brother Edmund Pendleton Barbour serves as a historically significant source for the safety of, hiring of, and caring for slaves. The agreement did not list a price for a slave's services but included the standard food and clothing clause along with an additional clause stating that "the boy Edwin not be allowed to cross the Libertyville millpond or the watercourse when it is high."
Both Barbour and his brother Thomas Barbour, also a physician, died of cholera during the 1848–1849 St. Louis cholera epidemic. The epidemic killed 4,500 people, one-tenth of the population of St. Louis. Barbour died on December 20, 1848 and his brother Thomas died the following year in June 1849. Barbour was initially buried in the Presbyterian Churchyard in St. Louis. Barbour was moved to Bellefontaine Cemetery by his sister-in-law, Mrs. Sarah C. Barbour, and reinterred on March 1, 1859 with his brother, Dr. Thomas Barbour and his niece, Helen Adele Barbour.
- Find A Grave (Mar 5, 2009). "Dr Sextus Barbour". Find A Grave. Retrieved 2009-04-05.
- Becky Bass Bonner & Josephine Lindsay Bass (05/29/2005 09:03:10 PM Central Standard Time). "Sextus BARBOUR". My Southern Family. Retrieved 2009-04-11.
- Green, Raleigh Travers (1900). Genealogical and historical notes on Culpeper county, Virginia. Raleigh Travers Green.
- University of Pennsylvania Archives and Records Center. "University of Pennsylvania Medical Department Matriculants, 1806-1852". University of Pennsylvania Archives and Records Center. Retrieved 2009-04-05.
- Miller, Susan (1998). Assuming the positions: cultural pedagogy and the politics of commonplace writing. Pittsburgh, Pennsylvania: University of Pittsburgh Press. ISBN 0-8229-5637-3.
- Henkin, David M. (2006). The postal age: the emergence of modern communications in nineteenth-century America. Chicago, Illinois: University of Chicago Press. ISBN 0-226-32720-5.
- Virginia Historical Society (November 27, 2006). "Manuscripts: Backus - Byrd". Guide to African American Manuscripts in the Collection of the Virginia Historical Society. Retrieved 2009-04-11.
- Rosenberg, Charles E. (1987). The cholera years: the United States in 1832, 1849, and 1866. Chicago: University of Chicago Press. ISBN 0-226-72677-0.