The underlying philosophy of the book is very different to, indeed contradictory to, the original Wells story in which the idea is repeatedly expressed of humans being completely helpless before the Martian invaders, as are other creatures towards the humans.
In various parts of the Wells book, the relationship between Martians and humans is compared to that between humans and cows, rabbits or ants. The humans' final deliverance, when the Martians succumb to earthly bacteria, is completely unconnected to their own efforts. Conversely, in the Wellmans' book Holmes, Watson and Challenger are plucky and resourceful humans, continually confronting and outwitting the Martians and completely undeterred by the invaders' technological superiority.
The story features a romantic relationship between Holmes and his landlady Mrs. Hudson, which Watson is completely oblivious to.