Shin-Zushi Station opened on April 1, 1930 as a station on the Shōnan Electric Railway, the predecessor to the current Keihin Electric Express Railway. Initially named Shōnan-Zushi Station(湘南逗子駅,Shōnan-Zushi-eki?), the first station was located 200 meters towards Kanagawa Hakkei than the present station. The line was extended another 400 meters in 1931, and a new terminal station, Shōnan-Zushi Station Hayama-Exit(湘南逗子駅葉山口,Shōnan-Zushi-eki Hayama-guchi?), with the former station renamed as Shōnan-Zushi Station Numama-Exit(湘南逗子駅沼間口,Shōnan-Zushi-eki Numama-guchi?). In 1942, the Shōnan Electric Railway became part of the Tokyu Corporation, and Shōnan-Zushi Station Hayama-Exit was closed. In 1948, the Keihin Electric Railway spun out from the Tokyu Corporation, and the station renamed Zushi-Kaigan Station(逗子海岸駅,Zushi-Kaigan-eki?), with the former Shōnan-Zushi Station Numama-Exit reopening as Keihin Zushi Station(京浜逗子駅,Keihin-Zushi-eki?). On March 2, 1985, both stations were replaced by a new station located approximately in between, called Shin-Zushi Station. A new station building was completed in March 1991.