"Shuffle" peaked at number 64 on the UK Singles Chart, becoming the band's second-most successful single. The single also debuted at number 40 and peaked at number 38 on the Billboard Alternative Songs chart in the United States, the band's first chart appearance in that country. The song also charted at number 60 on the BillboardJapan Hot 100 Singles chart.
The music video was uploaded to VEVO and YouTube on July 22, 2011. It features Lucy Rose, a fellow artist who is friends with the band. With over three million views, it is the band's most viewed video on YouTube and VEVO to date.