"Shut Me Up" is a single by Mindless Self Indulgence, released on September 12, 2006. "Shut Me Up" peaked at number 7 on the Billboard Hot Singles Sales chart and number 1 on the Hot Dance Singles Sales chart.
The video for "Shut Me Up" features Joshua Burian-Mohr as a store clerk who goes insane before going into seizures and exploding, several days after going to a concert by the band, according to "Dr. Alfred Carroll". It was directed by Jhonen Vasquez, the creator of the TV show Invader Zim as well as the comics Johnny the Homicidal Maniac, Squee! and I Feel Sick.
The video also features clips from Reefer Madness and a shot of Vasquez's hand-puppet.