S&P 500 Component
|Traded as||NASDAQ: SIAL|
|Headquarters||3050 Spruce St., St. Louis, Missouri 63103
|Key people||Rakesh Sachdev, President and CEO|
|Products||Life Science Technologies and Specialty Chemicals|
|Revenue||$2.6 billion (2012)|
Sigma-Aldrich Corporation is a life science and high technology company with over 9,600 employees and operations in 40 countries. Its chemical and biochemical products and kits are used in scientific research, biotechnology, pharmaceutical development, the diagnosis of disease, and as key components in high technology manufacturing.
Sigma Chemical Company and Aldrich Chemical Company merged in 1975, producing a current total corporate offering of more than 100,000 chemical products.
After the merger
Aldrich Chemical Co. merged with Sigma International, Ltd. to form Sigma-Aldrich Corporation in August 1975, when changing trends in chemical research confirmed the synergy to be realized from their complementary product offerings. Annual double-digit growth was the norm in the 80s and 90s, with significant expansion in facilities, major acquisitions and ventures into new market sectors. In December 2000 Sigma-Aldrich launched a strategic plan focusing the Company on “Leadership in Life Science and High Technology.” Other key initiatives on service and process improvements and a strong Internet presence have strengthened Sigma-Aldrich’s current position as a leading technology company.
Other key events
- 2001 – Acquisition of Isotec, a leader in stable isotope production, whose products are used in basic research and the diagnosis of disease; opening of $55 million Life Science and High Technology Center in St. Louis.
- 2002 – BioInformatics, LLC ranks Sigma-Aldrich first in service, catalogs and Web.
- 2003 – Doubling of US sales force; $57 million investment in production, R&D and warehousing.
- 2004 – Acquisitions of Ultrafine, a supplier of contract manufacturing services for drug development, and Tetrionics, a producer of high potency and cytotoxic active pharmaceutical ingredients.
- 2005 – Acquisitions of JRH Biosciences, a major industrial supplier of cell culture products for the pharmaceutical and biotechnology industries, for $370 million, and the Proligo Group, a global supplier of key genomics research tools; announced membership in The RNAi Consortium and joined leading institutions including MIT, Harvard, and Eli Lilly to develop and distribute genome-wide shRNA libraries globally.
- 2006 – Acquisitions of Beijing Superior Chemicals and Instruments Co. establishing a Wholly Foreign Owned Enterprise (WFOE) in China, Iropharm, Pharmorphix Ltd., and Advanced Separation Technologies, a manufacturer of products for chiral chromatography.
- 2007 – Acquisitions of Epichem Group Ltd. to expand capabilities in materials sciences and semiconductor markets, and Molecular Medicine BioServices to provide large-scale viral manufacturing capabilities; announced alliance with Sangamo BioSciences to develop zinc finger-based laboratory research reagents.
- 2008 – Introduced Prestige Antibodies line for proteomics and cell biology research; introduced ChIP kit technology for epigenetic research; Supelco introduced Ascentis Express HPLC columns with the Fused Core technology for high-speed, high-efficiency separation; BioInformatics, LLC ranks Sigma-Aldrich first for usefulness and ease-of-use of online and print catalogs.
- 2012 — acquisition of BioReliance, a provider of "biologic, specialized toxicology and animal health testing services". BioReliance had previously been acquired by Invitrogen and subsequently sold to Avista Capital Partners.
Key numbers for Sigma-Aldrich.
- $2.2 billion (2008)
- 100,000 chemical products (46,000 manufactured)
- 30,000 laboratory equipment products
- Approximately one million individual customers worldwide
- 88,000 accounts
Geographies (% of 2008 sales):
- United States 35%
- Europe 43%
- Canada, Asia Pacific, Latin America 22%
Organizational structure aligns to meet the specific needs of four customer segments:
- Research Biotech – specialty kits for life science researchers studying functional genomics, proteomics, and cell biology.
- Research Specialties – broad range of analytical, biochemical and chemical products.
- Research Essentials – offers the most commonly used laboratory chemicals and supplies through customized account management.
- SAFC – customized development and manufacturing services to the pharmaceutical, biopharmaceutical and diagnostic sectors.
Companies in the same biochemical sales sector include Bayer Aktienges Ads, Brenntag Holding GmbH & Co. KG, ThermoFisher Scientific, and VWR International, LLC. For stable isotopically labeled compounds used in biomedical research, competitors include Omicron Biochemicals, Cambridge Isotope Laboratories, Inc. (CIL) and many more 
- Analytical / Chromatography
- Research Essentials (Solvents, Buffers, Acids/Bases, General Reagents)
- Equipment, books & supplies
- Large scale chemicals & contract manufacturing
Aldrich is a supplier in the research and fine chemicals market. Aldrich provides organic and inorganic chemicals, building blocks, reagents, advanced materials and stable isotopes for chemical synthesis, medicinal chemistry and materials science. Aldrich's chemicals catalog, the "Aldrich Catalog and Handbook" is often used as a handbook due to the inclusion of structures, physical data, and literature references. Many students use it as a reference book, especially undergraduates, as it is offered free by request.
Sigma is the Sigma-Aldrich's main biochemical supplier, with offerings including antibiotics, buffers, carbohydrates, enzymes, forensic tools, hematology and histology, nucleotides, proteins, peptides, amino acids and their derivatives.
Sigma RBI produces specialized products for use in the field of cell signaling and neuroscience. Their offerings range from standard biochemical reagents to the latest cutting–edge research tools, including new ligands for receptors and ion channels, novel enzyme inhibitors, phosphospecific antibodies, key signal transduction enzymes, and assay kits for cell signaling.
ISOTEC provides isotopically labeled products for protein structure determination, peptide synthesis, proteomics, metabolic research, magnetic resonance imaging, nuclear magnetic resonance, breath test substrates, agriculture, as well as gas and gas mixes.
Riedel-de Haën was incorporated with Sigma-Aldrich in 1999 and manufactures reagents and standards.
Supelco is the chromotography products branch of Sigma-Aldrich. It provides chromatography columns and related tools for environmental, government, food and beverage, pharmaceutical, biotechnology, medical and chemical laboratories; sample preparation products and chemical reference standards.
Sigma-Aldrich Fine Chemicals
Sigma-Aldrich Fine Chemicals (SAFC) is the fine chemical supply branch of Sigma-Aldrich specializing in raw materials for cell culture products; customized services for raw materials, manufacturing of active pharmaceutical ingredients.
Sigma Life Science (formally Sigma-Genosys)
Sigma Advanced Genetic Engineering
Sigma Advanced Genetic Engineering (SAGE) Labs is a division within Sigma-Aldrich that specializes in genetic manipulation of in vivo systems for special research and development applications. It was formed in 2008 to investigate zinc finger nuclease technology and its application for disease research models. Located in St. Louis, Missouri, SAGE Labs have developed knockout rats for the study of human diseases and disorders (such as autism), which are sold for up to $95,000. SAGE also announced its first successful effort in creating a "knockout rabbit". Its facilities include a specific pathogen free, biosecure vivarium as well as research and development labs.
BioReliance by SAFC
BioReliance provides testing and manufacturing services to pharmaceutical and biopharmaceutical companies that span the product cycle from early pre-clinical development to licensed production. The company was acquired by Sigma Aldrich in January 2012. Facilities include state of the art labs in Rockville, MD, The United Kingdom, and Tokyo Japan.
- CEO of Sigma-Aldrich Dies; Successor Named
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- "Sigma-Aldrich Corp acquires Isotec Inc from Taiyo Nippon Sanso Corp".
- "BiofInformatics, LLC: Life Science Marketing—Who’s on Top?".
- "Sigma-Aldrich Corp acquires Ultrafine".
- "Sigma-Aldrich Corp acquires JRH Biosciences Inc from CSL Ltd".
- "NCBI on Sigma-Aldrich".
- "Sigma-Aldrich Corp acquires Beijing Superior Chem & Instr".
- "Sigma-Aldrich Corp acquires Pharmorphix Ltd".
- "Sigma-Aldrich Corp acquires Advanced Separation Tech Inc from Calgon Carbon Corp".
- "Sigma-Aldrich Corp acquires Epichem Group Ltd".
- Associated Press (9 Jan 2012), "Sigma-Aldrich to buy BioReliance Hldgs for $350M", News (Bioscience Technology), retrieved 11 Jan 2012
- Invitrogen Completes Divestiture of BioReliance (press release), Life Technologies, 12 April 2007, retrieved 11 Jan 2012
- "SEC Info - Sigma-Aldrich Corporation".
- "Hoover's Company Overview of Sigma-Aldrich Corporation".
- "Sigma-Aldrich Corporation Quarterly Report, May 2009".
- "Omicron Biochemicals".
- "Cambridge Isotope Laboratories, Inc.".
- "Stable Isotope Biochemicals". ISIS.
- "Carbolabs purchased". ICIS.