Sign of the Cross (disambiguation)

Sign of the Cross may refer to:

• Sign of the Cross, the ritual hand motion by Christians
• The Sign of the Cross (book): Travels in Catholic Europe, a book by Colm Tóibín
• The Sign of the Cross (play), 1895 play by Wilson Barrett
• The Sign of the Cross (film), directed by Cecil B. DeMille, based on the play
• Sign of the Cross (novel), 2006 novel by Chris Kuzneski
• "Sign of the Cross", a song by Iron Maiden on their album The X Factor
• "Sign of the Cross", a song by Terveet Kädet
• "Sign of the Cross", a song by Avantasia on their album The Metal Opera