Signe Wilkinson (born July 25, 1959, in Wichita Falls, Texas) is an editorial cartoonist best known for her work at the Philadelphia Daily News.
Wilkinson is the first female cartoonist to win the Pulitzer Prize for Editorial Cartooning (1992) and was once named "the Pennsylvania state vegetable substitute" by the former speaker of the Pennsylvania House of Representatives. She served as president of the Association of American Editorial Cartoonists from 1994-1995. In 2005 she published a collection of her work entitled One Nation, Under Surveillance.
In 2007, Wilkinson began a syndicated daily comic strip, Family Tree, for United Media. She decided to end the strip in August 2011, with the last strip appearing on August 27. In 2011, Wilkinson received a Visionary Woman Award from Moore College of Art & Design.