Signet ring cell carcinoma
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| Signet ring cell carcinoma | |
|---|---|
| Classification and external resources | |
 A metastatic signet ring cell carcinoma that arose from the breast. H&E stain. |
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| ICD-O: | M8490/3 |
| MeSH | D018279 |
Signet ring cell carcinoma is an epithelial malignancy characterized by the histologic appearance of signet ring cells.
It is a form of adenocarcinoma,[1] and it is most often found in the glandular cells of the stomach, but it may develop in other areas of the body [2]. Some cases (not all) are inherited, and these cases are often caused by mutations in the CDH1 gene [3].
[edit] Histologic appearance
Main article: signet ring cell
Signet ring cells resemble signet rings because a large vacuole full of mucin displaces the nucleus to the periphery.
[edit] Additional images
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[edit] References
- ^ el-Zimaity HM, Itani K, Graham DY (October 1997). "Early diagnosis of signet ring cell carcinoma of the stomach: role of the Genta stain". J. Clin. Pathol. 50 (10): 867–8. doi:10.1136/jcp.50.10.867. PMC 500272. PMID 9462273. http://jcp.bmj.com/cgi/pmidlookup?view=long&pmid=9462273.
- ^ "What is a Signet Cell Cancer?". CancerHelp UK. Cancer Research UK. http://cancerhelp.cancerresearchuk.org/about-cancer/cancer-questions/what-is-a-signet-cell-cancer. Retrieved 2/12/12.
- ^ "Office of Rare Diseases Research: Diffuse Gastric Cancer". National Institute of Health. National Institute of Health. pp. 84-85. http://rarediseases.info.nih.gov/GARD/QnASelected.aspx?diseaseID=10334. Retrieved 12/21/11.
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