Simone Collio (born December 27, 1979 in Cernusco sul Naviglio) is an Italian sprinter who specializes in the 60 and 100 metres. His personal best times are 6.55 seconds in the 60 metres (indoor) and 10.06 seconds in the 100 metres, the second all time best performance in the Italian ranking of 100 meters, after the 10.01 at altitude of Pietro Mennea.
Participating in the 2004 Summer Olympics, he achieved fourth place in his 100 metres heat, thus securing qualification to the second round. He then achieved sixth place in his second round heat, thus failing to secure qualification to the semi-finals. At the 2008 Summer Olympics in Beijing he competed at the 100 metres sprint and placed 3rd in his heat behind Richard Thompson and Martial Mbandjock in a time of 10.32 seconds. He qualified for the second round in which he failed to qualify for the semi finals as his time of 10.33 was the 7th time in his race, causing elimination. Together with Fabio Cerutti, Emanuele di Gregorio and Jacques Riparelli he also competed at the 4x100 metres relay. In their qualification heat they were disqualified and eliminated for the further competition.