He was a pupil of Titian in Venice, Peterzano debuted in Milan with the counterfaçade frescoes in San Maurizio al Monastero Maggiore (1573), influenced by Veronese and Tintoretto. In the same year he painted two canvasses with Histories of Sts. Paul and Barnabas for the church of San Barnaba, also in Milan. Also from the same period are a Pietà in the church of San Fedele and a Pentecost for San Paolo Converso (now in Sant'Eufemia).
Between 1578 and 1582 Peterzano executed frescoes in the presbytery of Garegnano Charterhouse, considered one of his masterworks. His last works, characterized by a cold monumental style, include a fresco with Stories of St. Anthony of Padua for the church of Sant'Angelo, a canvas with Madonna with Child and Saints for the parish church of Bioggio (Canton Ticino) and an altarpiece with St. Ambrose between Sts. Gervasius and Protasius in the Duomo of Milan (1592, now in the Pinacoteca Ambrosiana).
- Gregori, Mina (1992). "Sul venetismo di Simone Peterzano". Arte documento (6): pp. 263–269.
- Painters of reality: the legacy of Leonardo and Caravaggio in Lombardy, an exhibition catalog from The Metropolitan Museum of Art (fully available online as PDF), which contains material on Peterzano (see index)
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