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Sinecatechins (USAN, trade names Veregen and Polyphenon E) is an ointment of catechins (55% epigallocatechin gallate[1]) extracted from green tea and other components. It was the first botanical prescription drug approved by the US Food and Drug Administration, in 2006.[2]

The mode of action of sinecatechins is undetermined.[3] In its use for treatment of genital warts caused by the Human Papilloma Virus, Sinecatechins appear to have higher clearance rates than podophyllotoxin or imiquimod and causes less local irritation. However, clearance of lesions takes longer than with imiquimod.[4]


  1. ^ Mayeaux EJ, Dunton C (July 2008). "Modern management of external genital warts". J Low Genit Tract Dis 12 (3): 185–192. doi:10.1097/LGT.0b013e31815dd4b4. PMID 18596459. 
  2. ^ "FDA approves first anti-diarrheal drug for HIV/AIDS patients". United States of America Food and Drug Administration. Retrieved 1 January 2013. 
  3. ^ "Veregen label information" (PDF). Retrieved 2013-01-01. 
  4. ^ Meltzer SM, Monk BJ, Tewari KS (March 2009). "Green tea catechins for treatment of external genital warts". Am. J. Obstet. Gynecol. 200 (3): 233.e1–7. doi:10.1016/j.ajog.2008.07.064. PMID 19019336.