James Mackenzie (cardiologist)
|Sir James Mackenzie|
|Born||12 April 1853
|Died||26 January 1925
James Mackenzie was born at Pictonhill in Scone, where his father was a farmer. He left school at Perth Academy at fourteen and was apprenticed to a chemist. In 1873 he was offered a partnership in the chemist's firm but turned it down in order to study medicine. After private tuition in Latin he passed his entrance examination for the University of Edinburgh in October 1874 and qualified as a doctor in 1878. After completing his residency in Edinburgh, Mackenzie became a general practitioner in borough of Burnley in Lancashire, England where he continued to practise medicine for more than a quarter of a century. While he was engaged in a busy practice, he made many original observations, completed his MD degree on hemi-paraplegia spinalis (awarded by Edinburgh University in 1882) and had many scientific papers published. In 1887 he married Frances Jackson and honeymooned in Italy. They had two daughters Dorothy (born in 1888) and Jean (in 1893).
In his early studies Mackenzie used Riva-Rocci's sphygmograph to graphically record the pulse. Later Mackenzie devised a "polygraph," that allowed him to make simultaneous records of the arterial and venous pulses. He used this to evaluate the condition of the heart and to measure the AV interval. In 1890 he discovered premature ventricular contractions and use of the polygraph enabled Mackenzie to make original distinctions between harmless and dangerous types of pulse irregularities (arrhythmias). Mackenzie also demonstrated the efficacy of Digitalis in the treatment of arrhythmias and made important contributions to the study of the energetics of the heart muscle.
In November 1907 Mackenzie left Burnley for London and set up as a consulting physician where his reputation grew rapidly. In 1915 he was elected a Fellow of the Royal Society and was knighted. Three years later he founded the influential Mackenzie Institute of Clinical Research in St Andrews, which involved local General Practitioners in detailed long-term recording of patients' symptoms and illnesses.
Ironically Mackenzie himself suffered from an irregular heart beat, as a result of ischemic heart disease. He had his first heart attack in 1901, and recorded in himself the atrial fibrillation that accompanied this episode. By 1907 Mackenzie experienced frequent episodes of angina pectoris which he mentioned to Sir Thomas Lewis and in 1908 he had a severe episode of cardiac pain, probably due to a myocardial infarction. His angina continued after 1908 and became progressively worse until in January 1925 he had a prolonged and severe attack of angina and died at around 4am in the morning of 26 January 1925. Before his death Mackenzie has asked that his friend John Parkinson perform an autopsy after his death. This was done and showed extensive coronary artery disease and evidence of recent and old myocardial infarction. A description of the case was published in the British Heart Journal in 1939. Two early polygraphs and a bronze bust of Mackenzie are in the collection of the Tayside Medical History Museum.
- Mackenzie, James (1916). Principles of diagnosis and treatment in heart affections. London: Henry Frowde, Hodder & Stoughton.
- Mackenzie, James (1921). Heart disease and pregnancy. London: Henry Frowde, Hodder & Stoughton.
- Mackenzie, James (1909). Symptoms and their interpretation. London: Shaw & Sons.
- Mackenzie, James (1919). The future of medicine. London: Henry Frowde, Hodder & Stoughton.
- Mackenzie, James (1923). Angina pectoris. London: Henry Frowde, Hodder & Stoughton.
- Mackenzie, James (1908). Diseases of the heart. London: Henry Frowde, Hodder & Stoughton.
- Mackenzie, James (1902). The study of the pulse. Arterial, venous, and hepatic and of the movements of the heart. Edinburgh: Young J. Pentland.
- "Sir James Mackenzie, M.D. 1853-1925. General Practitioner".
- Hamish J.C. Davidson. Profiles In Cardiology: Sir James Mackenzie. Heart Views 2001; volume 2 http://www.hmc.org.qa/hmc/heartviews/issue11/history_of_medicine.htm
- Waterston D, Orr J, Cappell DF (July 1939). "SIR JAMES MACKENZIE'S HEART". Br Heart J 1 (3): 237–48. PMC 503856. PMID 18609821.
- Murdoch J, Denz-Penhey H (Oct–Dec 2007). "John Flynn meets James Mackenzie: developing the discipline of rural and remote medicine in Australia". Rural Remote Health 7 (4): 726. PMID 17944551.
- Murdoch JC. (October 1997). "Mackenzie's puzzle--the cornerstone of teaching and research in general practice.". Br J Gen Pract 47 (423): 656–8. PMC 1410103. PMID 9474833.
- McMichael J. (July 1981). "Sir James Mackenzie and atrial fibrillation--a new perspective". J R Coll Gen Pract 31 (228): 402–6. PMC 1972130. PMID 7033523.
- Krikler, D M (1988). "Sir James Mackenzie.". Clinical cardiology 11 (3) (Mar 1988). pp. 193–4. doi:10.1002/clc.4960110312. PMID 3281772.
- McCormick, J S (1981). "James Mackenzie and coronary heart disease.". The Journal of the Royal College of General Practitioners 31 (222) (Jan 1981). pp. 26–30. PMC 1971897. PMID 7021816.
- Borodulin, V I (1979). "[James Mackenzie and his place in the history of cardiology (on the 125th anniversary of his birth)]". Kardiologiia 19 (5) (May 1979). pp. 111–3. PMID 379406.
- STEVENSON, I (1953). "Sir James Mackenzie, 1853-1953.". Am. Heart J. 46 (4) (Oct 1953). pp. 479–84. doi:10.1016/0002-8703(53)90059-3. PMID 13092035.
- Fazekas, T; Liszkai, G; Bielik, H; Lüderitz, B (2003). "[History of atrial fibrillation]". Zeitschrift für Kardiologie 92 (2) (Feb 2003). pp. 122–7. doi:10.1007/s00392-003-0889-4. PMID 12596073.
- Fazekas, Tamás; Liszkai, Gizella (2002). "[History of atrial fibrillation]". Orvosi hetilap 143 (6) (Feb 10, 2002). pp. 285–9. PMID 11915187.
- Moorhead, R (1999). "Sir James Mackenzie (1853-1925): views on general practice education and research.". Journal of the Royal Society of Medicine 92 (1) (Jan 1999). pp. 38–43. PMC 1297041. PMID 10319040.
- A Biography of James Mackenzie
- Sir James Mackenzie on the Local Pioneers webpage of the Tayside Medical History Museum