Sirdarya Region (Uzbek: Sirdaryo viloyati, Сирдарё вилояти) is a viloyat (region) of Uzbekistan, located in the center of the country on the left bank of Syr Darya River. It borders with (Kazahstan), Tajikistan, Toshkent Region and Jizzakh Region. It covers an area of 5,100 km², and is mostly desert, with the Starving Steppe taking up a significant part of the region's area. The population is estimated to be around 648,100.
Syrdaryo Region is divided into 9 administrative districts. The capital is the city of Guliston (pop. est. 54,000 inhabitants). Other cities and towns include Baxt, Boyovut, Farhod, Qahramon, Sayhun, Sirdaryo, Shirin and Yangiyer.