Jack White conceived the idea of this song from a conversation he had with his daughter. Jack White told NME about the inspiration for the lyrics: "My daughter asked for a snack, and I said, 'what do you want to have?', and she said, 'I think I'll have 16 saltine crackers.' And I said, 'You'll have three!' At times I imagined that character was eating cracker rations on a lifeboat and he's remembering all these other things." It has been expressed that the album Blunderbuss is considered Jack Whites break up album since it formed after his failed marriage and subtly speaks of it. White told Steven Hyden, in an interview for www.avclub.com, that "Relationships of any kind are powerful, and they always influence an artist. It’s inescapable."The fast paced song could be put at the beginning of the album, to symbolize the chaos that ensued at the end of his marriage, with the rest of the album symbolizing the fallout of it all. White said, in an interview for NPR, that “If you have twenty guys in the room and you just bring in one girl, you change the entire mood and everyone plays different.”
White also told UK newspaper The Sun that he played the song to his daughter the day after she'd asked her dad for '16 saltine crackers': "I said, 'Listen, I wrote a song for you,'" he recalled, "and I played it back for her. She blushed and turned away. The next time I played the song for her, she said, 'Yeah, I never said that!'"
In the music video produced by AG Rojas, White sits on a windowsill with his hands tied in front of him with rope as two men painted white surround him while a boy painted in blue watches. The video also contains various clips of children doing random activities and ends with Jack White then tied up in a vehicle that the boy painted in blue is about to set on fire, but the video is cut before any fire is seen.