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Sixtus was a Roman name, a corruption of the Greek name "Ξυστος," meaning "polished," and originally Latinized "Xystus." In its Spanish form Sixto it is still used as a personal name. It is not to be confused with the common Roman praenomen "Sextus," meaning "sixth," though not necessarily denoting a sixth child.
- Pope Sixtus I (115/116–125)
- Pope Sixtus II (257–258)
- Pope Sixtus III (432–440)
- Pope Sixtus IV (1471–1484)
- Pope Sixtus V (1585–1590)
Other notable people named Sixtus include:
- Sixtus of Siena (1520–1569)
- Edmund Sixtus Muskie (1914–1996)
- Prince Sixtus of Bourbon-Parma (1886–1934)
- Prince Sixtus Henry of Bourbon-Parma (*1940)
- Sixtus Petraeus Father of former CIA Director David Petraeus
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