The random X-inactivation which occurs early in a developing female can result in skewed or non-random X-inactivation for a patch, tissue or organ.
During the process of X-inactivation one of the female's two X chromosome is inactivated. For the whole animal this is random but for an individual cell or tissue it is not. For example, fur patches of a tortoiseshell cat are orange or black due to inactivation of one X chromosome in the patch.
This becomes important in medicine when a carrier female of an X-linked recessive condition 'randomly' inactivates the chromosome containing the unaffected gene. This can lead to mild symptoms of the disease. An example is in about 10% of carrier mothers of hemophilic boys.
- Skewed X inactivation in healthy individuals and in different diseases
- X Inactivation.Skewed X Chromosome Inactivation: Manifesting carriers in X-linked neuromuscular disorders
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