Skytraders operates flights to support the Australian Antarctic Division's scientific research programme in Antarctica. Skytraders' website also states the company offers charter services to executives and VIPs during the Northern Hemisphere summer.
A Skytraders Airbus A319 has been used on behalf of the Australian government to ferry asylum seekers to the remote pacific island state of Nauru. According to the publication Crikey, Skytraders made a request to the global flight tracking organisation, FlightAware, that its asylum-seeker transportation flights not be tracked.
On 9 May 2010, an incident involving a Skytraders aircraft sparked an enquiry by the Australian Transport Safety Bureau (ATSB). A Skytraders Airbus A319, registered VH-VHD, taxied to the runway in the Cocos (Keeling) Islands for a flight to Christmas Island with the aircraft's integral staircase still extended as it moved across the tarmac. When the crew realised what had happened, they stopped the aircraft and retracted the staircase. Skytraders gave an undertaking to the ATSB to revise its operational procedures as a result of this incident.