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Sleeping sickness may refer to:
- African trypanosomiasis, a parasitic disease of people and animals (usually carried by the tsetse fly in rural areas)
- Animal trypanosomiasis, also known as nagana or animal African trypanosomiasis
- Eastern equine encephalitis virus, a zoonotic alphavirus and arbovirus present in North, Central and South America and the Caribbean
- Encephalitis lethargica, a form of encephalitis that swept the world in the 1920s
- Fatigue (medical), any one of several other medical conditions that cause lethargy
- Sleeping Sickness (film), a 2011 German film
- "Sleeping Sickness" (song), a 2008 song by the band City and Colour
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