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The slit lamp is an instrument consisting of a high-intensity light source that can be focused to shine a thin sheet of light into the eye. It is used in conjunction with a biomicroscope. The lamp facilitates an examination of the anterior segment, or frontal structures and posterior segment, of the human eye, which includes the eyelid, sclera, conjunctiva, iris, natural crystalline lens, and cornea. The binocular slit-lamp examination provides a stereoscopic magnified view of the eye structures in detail, enabling anatomical diagnoses to be made for a variety of eye conditions. A second, hand-held lens is used to examine the retina.
To fully understand the development of the slit lamp one must consider that with this invention and its improvements, it had to be accompanied by the introduction of new examination techniques. Two conflicting trends emerged in the development of the slit lamp. One trend originated from clinical research and aimed at an increase in functions and the introduction and application of the increasingly complex and advanced technology of the time The second trend originated from ophthalmologic practice and aimed at technical perfection and a restriction to useful methods and the applications of the instrument. The first man credited with developments in this field was Hermann Von Helmholtz (1850) when he invented the ophthalmoscope.
In ophthalmology and optometry, the term “slit lamp” is the most commonly referred to term however it would be more correct to call it the “slit lamp instrument”. Today’s instrument however is a combination of two separate developments in instruments. The two developments are the corneal microscope and that of the slit lamp itself. Though the slit lamp is a combination of these two developments, the first concept of the slit lamp dates back to 1911 credited to Alvar Gullstrand and his “large reflection-free ophthalmoscope.” The instrument was manufactured by the company Zeiss and consisted of a special illuminator that was connected by a small stand base through a vertical adjustable column. The base was able to move freely on a glass plate. The illuminator employed a Nernst glower which was later converted into a slit through a simple optical system. However, the instrument never received much attention and the term “slit lamp” did not appear in any literature again until 1914.
It wasn’t until 1919 that several improvements were made to the Gullstrand slit lamp made by Vogt Henker. First, a mechanical connection was made between lamp and ophthalmoscopic lens. This illumination unit was mounted to the table column with a double articulated arm. The binocular microscope was supported on a small stand and could be moved freely across the tabletop. Later, a cross slide stage was used for this purpose. Vogt introduced Koehler illumination, and the reddish shining Nernst glower was replaced with the brighter and whiter incandescent lamp. Special mention should be paid to the experiments that followed Henker’s improvements in 1919. On his improvements the Nitra lamp was replaced with a carbon arc lamp with a liquid filter. At this time the great importance of color temperature and the luminance of the light source for slit lamp examinations were recognized and the basis created for examinations in red-free light.
In the year 1926, the slit lamp instrument was redesigned. The vertical arrangement of the slit projector (slit lamp) made it an easy to handle instrument. For the first time, the axis through the patient’s eye was fixed at a common swiveling axis. This was a fundamental principle that was adopted for every slit lamp instrument developed. A limitation still with the instrument was it lacked a coordinate cross-slide stage for instrument adjustment but only a laterally adjustable chin rest for the patient. The importance of focal illumination had not yet been fully recognized.
In 1927, stereo cameras were developed and added to the slit lamp to further its use and application. In 1930, Rudolf Theil presented the further development of the slit lamp, encouraged by Hans Goldmann. Horizontal and vertical co-ordinate adjustments were performed with three control elements on the cross-slide stage. The common swivel axis for microscope and illumination system was connected to the cross-slide stage, which allowed it to be brought to any part of the eye to be examined. A further improvement was made in 1938. A control lever or joystick was used for the first time to allow for horizontal movement.
Following World War II the slit lamp was improved again. On this particular improvement the slit projector could be swiveled continuously across the front of the microscope. This was then improved again in 1950. In 1950, a company named Littmann redesigned the slit lamp again. They adopted the joystick control from the Goldmann instrument and the illumination path present in the Comberg instrument. Additionally Littmann added the stereo telescope system with a common objective magnification changer.
In 1965, the Model 100/16 Slit Lamp was produced based on the slit lamp by Littmann. This was soon followed by the Model 125/16 Slit Lamp in 1972. The only difference between the two models was their operating distances of 100 mm to 125 mm. With the introduction of the photo slit lamp further advancements were possible. In 1976, the development of the Model 110 Slit Lamp and the 210/211 Photo Slit Lamps were an innovation by which each were constructed from standard modules allowing for a wide range of different configurations. At the same time, halogen lamps replaced the old illumination systems to make them brighter and essentially daylight quality. From 1994 onwards, new slit lamps were introduced which took advantage of new technologies. The last major development was in 1996 in which included the advantages of new slit lamp optics. See also "From Lateral Illumination to Slit Lamp - An Outline of Medical History"
General procedure 
While a patient is seated in the examination chair, they rest their chin and forehead on a support to steady the head. Using the biomicroscope, the ophthalmologist or optometrist then proceeds to examine the patient's eye. A fine strip of paper, stained with fluorescein, a fluorescent dye, may be touched to the side of the eye; this stains the tear film on the surface of the eye to aid examination. The dye is naturally rinsed out of the eye by tears.
A subsequent test may involve placing drops in the eye in order to dilate the pupils. The drops take about 15 to 20 minutes to work, after which the examination is repeated, allowing the back of the eye to be examined. Patients will experience some light sensitivity for a few hours after this exam, and the dilating drops may also cause increased pressure in the eye, leading to nausea and pain. Patients who experience serious symptoms are advised to seek medical attention immediately.
Adults need no special preparation for the test; however children may need some preparation, depending on age, previous experiences, and level of trust.
Variations in methods 
Observation by optical section 
Observation with an optical section or direct focal illumination is the most frequently applied method of examination with the slit lamp. With this method, the axes of illuminating and viewing path intersect in the area of the anterior eye media to be examined, for example, the individual corneal layers
Direct diffuse illumination 
If media, especially that of the cornea, are opaque, optical section images are often impossible depending on severity. In these cases, direct diffuse illumination may be used to advantage. For this, the slit is opened very wide and a diffuse, attenuated survey illumination is produced by inserting a ground glass screen or diffuser in the illuminating path. "Wide beam" illumination is the only type that has the light source set wide open. Its main purpose is to illuminate as much of the eye and its adnexa at once for general observation.
Indirect illumination 
With this method, light enters the eye through a narrow to medium slit (2 to 4 mm) to one side of the area to be examined. The axes of illuminating and viewing path do not intersect at the point of image focus, to achieve this; the illuminating prism is decentered by rotating it about its vertical axis off the normal position. In this way, reflected, indirect light illuminates the area of the anterior chamber or cornea to be examined. The observed corneal area then lies between the incident light section through the cornea and the irradiated area of the iris. Observation is thus against a comparatively dark background.
In certain cases, illumination by optical section does not yield sufficient information or is impossible. This is the case, for example, when larger, extensive zones or spaces of the ocular media are opaque. Then the scattered light that is not very bright normally is absorbed. A similar situation arises when areas behind the crystalline lens are to be observed. In this case the observation beam must pass a number of interfaces that may reflect and attenuate the light.
Scattering sclero-corneal illumination 
With this type of illumination, a wide light beam is directed onto the limbal region of the cornea at an extremely low angle of incidence and with a laterally de-centered illuminating prism. Adjustment must allow the light beam to transmit through the corneal parenchymal layers according to the principle of total reflection allowing the interface with the cornea to be brightly illuminated. The magnification should be selected so that the entire cornea can be seen at a glance.
Fundus observation and gonioscopy with the slit lamp 
Fundus (eye) observation is known by the ophthalmic and the use of fundus cameras. With the slit lamp, however, direct observation of the fundus is impossible due to the refractive power of the ocular media. In other words: the far point of the eye (punctum remotum) is so distant in front of (myopia) or behind (hyperopia) that the microscope cannot be focused. The use of auxiliary optics - generally as a lens – makes it possible however to bring the far point within the focusing range of the microscope. For this various auxiliary lenses are in use that range in optical properties and practical application.
The slit lamp exam may detect many diseases of the eye, including:
- Corneal injury such as corneal ulcer or corneal swelling
- Diabetic retinopathy
- Fuchs' dystrophy
- Keratoconus (Fleischer ring)
- Macular degeneration
- Retinal detachment
- Retinal vessel occlusion
- Retinitis pigmentosa
- Sjögren's syndrome
- Wilson's disease (Kayser-Fleischer ring)
One sign that may be seen in slit lamp examination is a "flare", which is when the slit-lamp beam is seen in the anterior chamber. This occurs when there is breakdown of the blood-aqueous barrier with resultant exudation of protein.
- "Eye Examination with the Slit Lamp", Carl Zeiss Meditec, AG, p. 33, accessed: February 6, 2011.
- "Eye Examination with the Slit Lamp", Zeiss, p. 33
- "Eye Examination with the Slit Lamp", Zeiss, p. 34
- "Eye Examination with the Slit Lamp", Zeiss, p. 35
- "Eye Examination with the Slit Lamp", Zeiss, p. 36
- "Eye Examination with the Slit Lamp", Zeiss, p. 37
- "Eye Examination with the Slit Lamp", Zeiss, p. 38
- "Eye Examination with the Slit Lamp", Zeiss, p. 39
- "From Lateral Illumination to Slit Lamp - An Outline of Medical History", Koppenhöfer, Eilhard - online published 2012
- "Eye Examination with the Slit Lamp", Zeiss, p. 14
- "Eye Examination with the Slit Lamp", Zeiss, p. 16
- Indiana University School of Optometry. "Slit Lamp Illumination Types". Indiana University, Indiana: 2007. Retrieved 6 February 2011.
- "Eye Examination with the Slit Lamp", Zeiss, p. 17
- "Eye Examination with the Slit Lamp", Zeiss, p. 18
- "Eye Examination with the Slit Lamp", Zeiss, p. 19
- Chapter 32 in Classification, Symptoms, and Signs of Uveitis by DEBRA A. GOLDSTEIN and HOWARD H. TESSLER. 2006 Edition
Further reading 
|Wikimedia Commons has media related to: Slit lamp|
- Vivino MA, Chintalagiri S, Trus B, Dati.les M., “Development of a Scheimpflug slit lamp camera system for quantitative densitometric analysis”, Computer Systems Laboratory, National Eye Institute, National Institutes of Health, Bethesda, MD 20892. Eye (Lond). 1993;7 ( Pt 6):791-8.
- "Slit-Lamp Gonioscopy." Postgraduate Medical Journal 39.451 (1963): 310.
- Jobe, Frederick W. Slit Lamp. United States BAUSCH & LOMB, assignee. Patent "2235319" Mar. 1941.
- Nikon, Slit Lamp CS-1 Microscope, accessed February 6, 2011.
- Ledford, Janice K. and Sanders, Valerie N. "The slit lamp primer", 2nd Edition, SLACK Incorporated, ISBN 978-1-55642-747-3, published 2006.
- Schwartz, Gary S., "The eye exam: a complete guide", pp. 109-128 Slit Lamp Biomicroscopy, SLACK Incorporated, ISBN 978-1-55642-755-8, published 2006.
- Koppenhöfer, Eilhard, From Lateral Illumination to Slit Lamp — An Outline of Medical History, online published 2012