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Slough is a town in Berkshire, England.
Slough may also refer to:
- Slough (hydrology), a muddy or marshy area, or a swamp or shallow lake system
Biology and medicine
- Sloughing, shedding or casting off dead tissue
- Skin sloughing, process of shedding dead surface cells from the skin
- Slough (moulting), in animals, to shed the skin or shell
- Slough sedge, the grass-like plant Carex obnupta
- Slough, a state of depression (mood)
- Eschar, a slough or piece of dead tissue
- "Slough" (poem), by Sir John Betjeman about the town of Slough
- Slough of Despond, fictional bog originally featured in A Pilgrim's Progress by John Bunyan
- Alan Slough (born 1947), footballer who played for Luton Town and Fulham
- John P. Slough (1829–1867), American politician and general
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