Small Cajal body-specific RNA
|Small Cajal body specific RNA 1|
|Predicted secondary structure of Small Cajal body specific RNA 1|
|RNA type||gene, snRNA, snoRNA, scaRNA;|
Small Cajal body-specific RNAs (scaRNAs) are a class of small nucleolar RNAs (snoRNAs) that specifically localise to the Cajal body, a nuclear organelle involved in the biogenesis of small nuclear ribonucleoproteins (snRNPs or snurps). ScaRNAs guide the modification (methylation and pseudouridylation) of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.
The first scaRNA identified was U85. It is unlike typical snoRNAs in that it is a composite C/D box and H/ACA box snoRNAs and can guide both pseudouridylation and 2'-O-methylation. Not all scaRNAs are composite C/D and H/ACA box snoRNA and most scaRNAs are structurally and functionally indistinguishable from snoRNAs, directing ribosomal RNA (rRNA) modification in the nucleolus.
Small Cajal body-specific RNA 1
In molecular biology, Small Cajal body-specific RNA 1 (also known as scaRNA1 or ACA35) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U2 spliceosomal RNA.
scaRNA1 is a non-coding RNA, which are functional products of gene but not translated into a protein. Such RNA molecules usually contain important secondary structure or ligand binding motifs and are involved in many important biological processes in the cell. To be specific, scaRNAs are a class of small nucleolar RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.
scaRNA1 belongs to the H/ACA box class of guide RNAs, as it has the predicted hairpin-hinge-hairpin-tail structure, conserved H/ACA-box motifs and is found associated with GAR1 protein. It is predicted to guide pseudouridylation of the U2 spliceosomal RNA at residue U89.
- Jády BE, Kiss T (2001). "A small nucleolar guide RNA functions both in 2′-O-ribose methylation and pseudouridylation of the U5 spliceosomal RNA". EMBO J. 20 (3): 541–51. doi:10.1093/emboj/20.3.541. PMC 133463. PMID 11157760.
- Darzacq, X; Jady BE; Verheggen C; Kiss AM; Bertrand E; Kiss T (2002). "Cajal body-specific small nuclear RNAs: a novel class of 2′-O-methylation and pseudouridylation guide RNAs". EMBO J. 21 (11): 2746–2756. doi:10.1093/emboj/21.11.2746. PMC 126017. PMID 12032087.
- Kiss, Arnold M.; Jády, Beáta E.; Bertrand, Edouard; Kiss, Tamás (2004). "Human Box H/ACA Pseudouridylation Guide RNA Machinery". Molecular and Cellular Biology 24 (13): 5797–5807. doi:10.1128/MCB.24.13.5797-5807.2004. PMC 480876. PMID 15199136.
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