Small Cajal body specific RNA 11

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Small Cajal body specific RNA 11
Predicted secondary structure and sequence conservation of SCARNA11
Symbol SCARNA11
Alt. Symbols snoACA57
Rfam RF00564
Other data
RNA type Gene; snRNA; snoRNA; scaRNA
Domain(s) Eukaryota
GO 0006396 0015030 0005730
SO 0000275

In molecular biology, Small Cajal body specific RNA 11 (also known as scaRNA11 or ACA57) is a small nucleolar RNA found in Cajal bodies.

scaRNAs are a specific class of small nuclear RNAs which localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.[1][2] ACA57 belongs to the H/ACA box class of guide RNAs as it has the predicted hairpin-hinge-hairpin-tail structure, conserved H/ACA-box motifs and is found associated with GAR1.[1] ACA57 is predicted to guide the pseudouridylation of the U5 spliceosomal RNA at position U43.[3]


  1. ^ a b Darzacq, Xavier; Jády, Beáta E.; Verheggen, Céline; Kiss, Arnold M.; Bertrand, Edouard; Kiss, Tamás (2002). "Cajal body-specific small nuclear RNAs: A novel class of 2'-O-methylation and pseudouridylation guide RNAs". The EMBO Journal 21 (11): 2746–2756. doi:10.1093/emboj/21.11.2746. PMC 126017. PMID 12032087.  edit
  2. ^ Lestrade, Laurent; Weber, Michel J. (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research 34 (Supplement 1: Database Issue): D158–D162. doi:10.1093/nar/gkj002. PMC 1347365. PMID 16381836. CiteSeerX:  edit
  3. ^ Kiss, Arnold M.; Jády, Beáta E.; Bertrand, Edouard; Kiss, Tamás (2004). "Human Box H/ACA Pseudouridylation Guide RNA Machinery". Molecular and Cellular Biology 24 (13): 5797–5807. doi:10.1128/MCB.24.13.5797-5807.2004. PMC 480876. PMID 15199136.  edit

External links[edit]