Small Cajal body specific RNA 13

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Small Cajal body specific RNA 13
RF00231.jpg
Predicted secondary structure and sequence conservation of SCARNA13
Identifiers
Symbol SCARNA13
Alt. Symbols U93
Rfam RF00231
Other data
RNA type Gene; snRNA; snoRNA; scaRNA
Domain(s) Eukaryota
GO 0006396 0015030 0005730
SO 0000275

In molecular biology, Small Cajal body specific RNA 13 (also known as scaRNA13 or U93) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U2 and U5 spliceosomal RNA.

scaRNAs are a specific class of small nucleolar RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.[1]

U93 is composed of two tandemly arranged box H/ACA box sequence motifs and belongs to the H/ACA box class of guide RNAs.[2] U93 is predicted to guide pseudouridylation of U2 spliceosomal snRNA residue U54 and residue U53 of snRNA U5.[2][3][4]

References[edit]

  1. ^ Darzacq, Xavier; Jády, Beáta E.; Verheggen, Céline; Kiss, Arnold M.; Bertrand, Edouard; Kiss, Tamás (2002). "Cajal body-specific small nuclear RNAs: A novel class of 2'-O-methylation and pseudouridylation guide RNAs". The EMBO Journal 21 (11): 2746–2756. doi:10.1093/emboj/21.11.2746. PMC 126017. PMID 12032087.  edit
  2. ^ a b Kiss AM, Jády BE, Darzacq X, Verheggen C, Bertrand E, Kiss T (2002). "A Cajal body-specific pseudouridylation guide RNA is composed of two box H/ACA snoRNA-like domains". Nucleic Acids Res. 30 (21): 4643–9. doi:10.1093/nar/gkf592. PMC 135803. PMID 12409454. 
  3. ^ Lestrade, Laurent; Weber, Michel J. (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research 34 (Supplement 1: Database Issue): D158–D162. doi:10.1093/nar/gkj002. PMC 1347365. PMID 16381836. CiteSeerX: 10.1.1.105.7552.  edit
  4. ^ Schattner P, Barberan-Soler S, Lowe TM (2006). "A computational screen for mammalian pseudouridylation guide H/ACA RNAs". RNA 12 (1): 15–25. doi:10.1261/rna.2210406. PMC 1370881. PMID 16373490. 

External links[edit]