Small Cajal body specific RNA 15

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Small Cajal body specific RNA 15
RF00426.jpg
Predicted secondary structure and sequence conservation of SCARNA15
Identifiers
Symbol SCARNA15
Alt. Symbols snoACA45
Rfam RF00426
Other data
RNA type Gene; snRNA; snoRNA; scaRNA
Domain(s) Eukaryota
GO 0006396 0015030 0005730
SO 0000275

Small Cajal body specific RNA 15 (also known as SCARNA15 or ACA45) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation (isomerisation of uridine to pseudouridine) of U1 spliceosomal RNA.

scaRNAs are a specific class of small nucleolar RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.[1]

ACA45 belongs to the H/ACA box class of guide RNAs as it has the predicted hairpin-hinge-hairpin-tail structure, the conserved H/ACA-box motifs and is found associated with GAR1.[2] ACA45 is predicted to guide the pseudouridylation of residue U37 of the U2 spliceosomal snRNA.[3]

It has been shown that human ACA45 can be processed into a 21 nucleotides long mature miRNA by the RNAse III family endoribonuclease dicer.[4] This snoRNA product has previously been identified as mmu-miR-1839[5] and was shown to be processed independent of the other miRNA generating endoribonuclease drosha.[6]

References[edit]

  1. ^ Darzacq, Xavier; Jády, Beáta E.; Verheggen, Céline; Kiss, Arnold M.; Bertrand, Edouard; Kiss, Tamás (2002). "Cajal body-specific small nuclear RNAs: A novel class of 2'-O-methylation and pseudouridylation guide RNAs". The EMBO Journal 21 (11): 2746–2756. doi:10.1093/emboj/21.11.2746. PMC 126017. PMID 12032087.  edit
  2. ^ Kiss, Arnold M.; Jády, Beáta E.; Bertrand, Edouard; Kiss, Tamás (2004). "Human Box H/ACA Pseudouridylation Guide RNA Machinery". Molecular and Cellular Biology 24 (13): 5797–5807. doi:10.1128/MCB.24.13.5797-5807.2004. PMC 480876. PMID 15199136.  edit
  3. ^ Lestrade, Laurent; Weber, Michel J. (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research 34 (Supplement 1: Database Issue): D158–D162. doi:10.1093/nar/gkj002. PMC 1347365. PMID 16381836. CiteSeerX: 10.1.1.105.7552.  edit
  4. ^ Ender, C.; Krek, A.; Friedländer, M.; Beitzinger, M.; Weinmann, L.; Chen, W.; Pfeffer, S.; Rajewsky, N.; Meister, G. (2008). "A human snoRNA with microRNA-like functions". Molecular Cell 32 (4): 519–528. doi:10.1016/j.molcel.2008.10.017. PMID 19026782.  edit
  5. ^ "mmu-miR-1839". MiRBase. 
  6. ^ Babiarz, J.; Ruby, J.; Wang, Y.; Bartel, D.; Blelloch, R. (2008). "Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs". Genes & Development 22 (20): 2773–2785. doi:10.1101/gad.1705308. PMC 2569885. PMID 18923076.  edit

External links[edit]