Small Cajal body specific RNA 6 (also known as SCARNA6 or U88) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation ( isomerisation of uridine to pseudouridine) of U5 spliceosomal RNA.
scaRNAs are a specific class of
small nucleolar RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12 [1 ]
U88 is found associated with both fibrillarin and Gar1p and co-localises with coilin in Cajal bodies.
It is an unusual guide RNA in that it its composed of both [1 ] H/ACA box and a C/D box conserved domains. It is predicted to guide 2'- O-methylation of residue U41 of the U5 snRNA. [1 ]
U88 is also closely related to other human snoRNAs scaRNA U87 and a mouse homologue MBI-46.
In the human genome both U88 and U87 scaRNAs share the same host gene. [2 ] [1 ] [3 ]
References [ edit ]
^ a b c d Darzacq, Xavier; Jády, Beáta E.; Verheggen, Céline; Kiss, Arnold M.; Bertrand, Edouard; Kiss, Tamás (2002). "Cajal body-specific small nuclear RNAs: A novel class of 2'-. O-methylation and pseudouridylation guide RNAs" The EMBO Journal 21 (11): 2746–2756. doi: 10.1093/emboj/21.11.2746. PMC 126017. PMID 12032087.
^ Huttenhofer, Alexander; Kiefmann, Martin; Meier-Ewert, Sebastian; O'Brien, John; Lehrach, Hans; Bachellerie, Jean-Pierre; Brosius, Jürgen (1 June 2001). "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". The EMBO Journal 20 (11): 2943–2953. doi: 10.1093/emboj/20.11.2943. PMC 125495. PMID 11387227.
^ Lestrade, Laurent; Weber, Michel J. (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research 34 (Supplement 1: Database Issue): D158–D162. doi: 10.1093/nar/gkj002. PMC 1347365. PMID 16381836. CiteSeerX: . 10.1.1.105.7552
External links [ edit ]