Small nuclear ribonucleoprotein D1

Small nuclear ribonucleoprotein D1 polypeptide 16kDa
PDB rendering based on 1b34.
Available structures PDB 1B34, 3CW1
Identifiers
Symbols	SNRPD1; HsT2456; SMD1; SNRPD; Sm-D1
External IDs	OMIM: 601063 MGI: 98344 HomoloGene: 107532 GeneCards: SNRPD1 Gene
Gene Ontology Molecular function • RNA binding • protein binding Cellular component • nucleus • nucleoplasm • nucleoplasm • U12-type spliceosomal complex • cytoplasm • cytosol • cytosol • small nuclear ribonucleoprotein complex • catalytic step 2 spliceosome Biological process • spliceosome assembly • spliceosomal snRNP assembly • nuclear mRNA splicing, via spliceosome • nuclear mRNA splicing, via spliceosome • RNA splicing • gene expression • RNA metabolic process • ncRNA metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6632	20641
Ensembl	ENSG00000167088	ENSMUSG00000002477
UniProt	P62314	P62315
RefSeq (mRNA)	NM_006938.2	NM_009226.4
RefSeq (protein)	NP_008869.1	NP_033252.1
Location (UCSC)	Chr 18: 19.19 – 19.21 Mb	Chr 18: 10.62 – 10.63 Mb
PubMed search	[1]	[2]

Small nuclear ribonucleoprotein Sm D1 is a protein that in humans is encoded by the SNRPD1 gene.

This gene encodes a small nuclear ribonucleoprotein that belongs to the SNRNP core protein family. The protein may act as a charged protein scaffold to promote SNRNP assembly or strengthen SNRNP-SNRNP interactions through nonspecific electrostatic contacts with RNA.

Interactions

Small nuclear ribonucleoprotein D1 has been shown to interact with DDX20, CLNS1A, CDC5L, Small nuclear ribonucleoprotein D2 and SMN1.

Further reading

• Renz M, Heim C, Bräunling O, et al. (1989). "Expression of the major human ribonucleoprotein (RNP) autoantigens in Escherichia coli and their use in an EIA for screening sera from patients with autoimmune diseases". Clin. Chem. 35 (9): 1861–3. PMID 2528429. 
• Rokeach LA, Haselby JA, Hoch SO (1988). "Molecular cloning of a cDNA encoding the human Sm-D autoantigen". Proc. Natl. Acad. Sci. U.S.A. 85 (13): 4832–6. doi:10.1073/pnas.85.13.4832. PMC 280530. PMID 3260384. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=280530. 
• Sun D, Ou YC, Hoch SO (1997). "Analysis of genes for human snRNP Sm-D1 protein and identification of the promoter sequence which shows segmental homology to the promoters of Sm-E and U1 snRNA genes". Gene 189 (2): 245–54. doi:10.1016/S0378-1119(96)00858-X. PMID 9168134. 
• Liu Q, Fischer U, Wang F, Dreyfuss G (1997). "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell 90 (6): 1013–21. doi:10.1016/S0092-8674(00)80367-0. PMID 9323129. 
• Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (1998). "Multiple protein: protein interactions between the snRNP common core proteins". Exp. Cell Res. 237 (1): 63–9. doi:10.1006/excr.1997.3750. PMID 9417867. 
• Kambach C, Walke S, Young R, et al. (1999). "Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs". Cell 96 (3): 375–87. doi:10.1016/S0092-8674(00)80550-4. PMID 10025403. 
• Charroux B, Pellizzoni L, Perkinson RA, et al. (2000). "Gemin3: A Novel Dead Box Protein That Interacts with Smn, the Spinal Muscular Atrophy Gene Product, and Is a Component of Gems". J. Cell Biol. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC 2168095. PMID 10601333. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2168095. 
• Charroux B, Pellizzoni L, Perkinson RA, et al. (2000). "Gemin4: A Novel Component of the Smn Complex That Is Found in Both Gems and Nucleoli". J. Cell Biol. 148 (6): 1177–86. doi:10.1083/jcb.148.6.1177. PMC 2174312. PMID 10725331. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2174312. 
• Mammoto A, Sasaki T, Kim Y, Takai Y (2000). "Physical and functional interaction of rabphilin-11 with mammalian Sec13 protein. Implication in vesicle trafficking". J. Biol. Chem. 275 (18): 13167–70. doi:10.1074/jbc.C000096200. PMID 10747849. 
• Brahms H, Raymackers J, Union A, et al. (2000). "The C-terminal RG dipeptide repeats of the spliceosomal Sm proteins D1 and D3 contain symmetrical dimethylarginines, which form a major B-cell epitope for anti-Sm autoantibodies". J. Biol. Chem. 275 (22): 17122–9. doi:10.1074/jbc.M000300200. PMID 10747894. 
• Meister G, Bühler D, Laggerbauer B, et al. (2000). "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins". Hum. Mol. Genet. 9 (13): 1977–86. doi:10.1093/hmg/9.13.1977. PMID 10942426. 
• Ajuh P, Kuster B, Panov K, et al. (2001). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=305846. 
• Selenko P, Sprangers R, Stier G, et al. (2001). "SMN tudor domain structure and its interaction with the Sm proteins". Nat. Struct. Biol. 8 (1): 27–31. doi:10.1038/83014. PMID 11135666. 
• Urlaub H, Raker VA, Kostka S, Lührmann R (2001). "Sm protein–Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure". EMBO J. 20 (1–2): 187–96. doi:10.1093/emboj/20.1.187. PMC 140196. PMID 11226169. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=140196. 
• Friesen WJ, Massenet S, Paushkin S, et al. (2001). "SMN, the product of the spinal muscular atrophy gene, binds preferentially to dimethylarginine-containing protein targets". Mol. Cell 7 (5): 1111–7. doi:10.1016/S1097-2765(01)00244-1. PMID 11389857. 
• Park JW, Voss PG, Grabski S, et al. (2001). "Association of galectin-1 and galectin-3 with Gemin4 in complexes containing the SMN protein". Nucleic Acids Res. 29 (17): 3595–602. doi:10.1093/nar/29.17.3595. PMC 55878. PMID 11522829. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=55878. 
• Friesen WJ, Paushkin S, Wyce A, et al. (2001). "The Methylosome, a 20S Complex Containing JBP1 and pICln, Produces Dimethylarginine-Modified Sm Proteins". Mol. Cell. Biol. 21 (24): 8289–300. doi:10.1128/MCB.21.24.8289-8300.2001. PMC 99994. PMID 11713266. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=99994. 
• Gubitz AK, Mourelatos Z, Abel L, et al. (2002). "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins". J. Biol. Chem. 277 (7): 5631–6. doi:10.1074/jbc.M109448200. PMID 11714716.