Small nuclear ribonucleoprotein D1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Small nuclear ribonucleoprotein D1 polypeptide 16kDa
Protein SNRPD1 PDB 1b34.png
PDB rendering based on 1b34.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SNRPD1 ; HsT2456; SMD1; SNRPD; Sm-D1
External IDs OMIM601063 MGI98344 HomoloGene107532 GeneCards: SNRPD1 Gene
RNA expression pattern
PBB GE SNRPD1 202690 s at tn.png
PBB GE SNRPD1 202691 at tn.png
More reference expression data
Species Human Mouse
Entrez 6632 20641
Ensembl ENSG00000167088 ENSMUSG00000002477
UniProt P62314 P62315
RefSeq (mRNA) NM_001291916 NM_009226
RefSeq (protein) NP_001278845 NP_033252
Location (UCSC) Chr 18:
19.19 – 19.21 Mb
Chr 18:
10.62 – 10.63 Mb
PubMed search [1] [2]

Small nuclear ribonucleoprotein Sm D1 is a protein that in humans is encoded by the SNRPD1 gene.[1][2]

This gene encodes a small nuclear ribonucleoprotein that belongs to the SNRNP core protein family. The protein may act as a charged protein scaffold to promote SNRNP assembly or strengthen SNRNP-SNRNP interactions through nonspecific electrostatic contacts with RNA.[3]


Small nuclear ribonucleoprotein D1 has been shown to interact with DDX20,[4] CLNS1A,[5] CDC5L,[6] Small nuclear ribonucleoprotein D2[7][8] and SMN1.[9][10][11]


  1. ^ Lehmeier T, Raker V, Hermann H, Luhrmann R (January 1995). "cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction". Proc Natl Acad Sci U S A 91 (25): 12317–21. doi:10.1073/pnas.91.25.12317. PMC 45428. PMID 7527560. 
  2. ^ Lehmeier T, Foulaki K, Luhrmann R (January 1991). "Evidence for three distinct D proteins, which react differentially with anti-Sm autoantibodies, in the cores of the major snRNPs U1, U2, U4/U6 and U5". Nucleic Acids Res 18 (22): 6475–84. doi:10.1093/nar/18.22.6475. PMC 332598. PMID 1701240. 
  3. ^ "Entrez Gene: SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa". 
  4. ^ Charroux, B; Pellizzoni L; Perkinson R A; Shevchenko A; Mann M; Dreyfuss G (Dec 1999). "Gemin3: A Novel Dead Box Protein That Interacts with Smn, the Spinal Muscular Atrophy Gene Product, and Is a Component of Gems". J. Cell Biol. (UNITED STATES) 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. ISSN 0021-9525. PMC 2168095. PMID 10601333. 
  5. ^ Friesen, W J; Paushkin S; Wyce A; Massenet S; Pesiridis G S; Van Duyne G; Rappsilber J; Mann M; Dreyfuss G (Dec 2001). "The Methylosome, a 20S Complex Containing JBP1 and pICln, Produces Dimethylarginine-Modified Sm Proteins". Mol. Cell. Biol. (United States) 21 (24): 8289–300. doi:10.1128/MCB.21.24.8289-8300.2001. ISSN 0270-7306. PMC 99994. PMID 11713266. 
  6. ^ Ajuh, P; Kuster B; Panov K; Zomerdijk J C; Mann M; Lamond A I (Dec 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. (ENGLAND) 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. ISSN 0261-4189. PMC 305846. PMID 11101529. 
  7. ^ Fury, M G; Zhang W; Christodoulopoulos I; Zieve G W (November 1997). "Multiple protein: protein interactions between the snRNP common core proteins". Exp. Cell Res. (UNITED STATES) 237 (1): 63–9. doi:10.1006/excr.1997.3750. ISSN 0014-4827. PMID 9417867. 
  8. ^ Kambach, C; Walke S; Young R; Avis J M; de la Fortelle E; Raker V A; Lührmann R; Li J; Nagai K (February 1999). "Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs". Cell (UNITED STATES) 96 (3): 375–87. doi:10.1016/S0092-8674(00)80550-4. ISSN 0092-8674. PMID 10025403. 
  9. ^ Meister, G; Bühler D; Laggerbauer B; Zobawa M; Lottspeich F; Fischer U (August 2000). "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins". Hum. Mol. Genet. (ENGLAND) 9 (13): 1977–86. doi:10.1093/hmg/9.13.1977. ISSN 0964-6906. PMID 10942426. 
  10. ^ Liu, Q; Fischer U; Wang F; Dreyfuss G (September 1997). "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell (UNITED STATES) 90 (6): 1013–21. doi:10.1016/S0092-8674(00)80367-0. ISSN 0092-8674. PMID 9323129. 
  11. ^ Friesen, W J; Dreyfuss G (August 2000). "Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN)". J. Biol. Chem. (UNITED STATES) 275 (34): 26370–5. doi:10.1074/jbc.M003299200. ISSN 0021-9258. PMID 10851237. 

Further reading[edit]