Small nuclear ribonucleoprotein D2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Small nuclear ribonucleoprotein D2 polypeptide 16.5kDa
Protein SNRPD2 PDB 1b34.png
PDB rendering based on 1b34.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SNRPD2 ; SMD2; SNRPD1; Sm-D2
External IDs OMIM601061 MGI98345 HomoloGene3381 GeneCards: SNRPD2 Gene
Species Human Mouse
Entrez 6633 107686
Ensembl ENSG00000125743 ENSMUSG00000040824
UniProt P62316 P62317
RefSeq (mRNA) NM_004597 NM_026943
RefSeq (protein) NP_004588 NP_081219
Location (UCSC) Chr 19:
46.19 – 46.2 Mb
Chr 7:
19.15 – 19.15 Mb
PubMed search [1] [2]

Small nuclear ribonucleoprotein Sm D2 is a protein that in humans is encoded by the SNRPD2 gene.[1][2][3]

The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.[3]


Small nuclear ribonucleoprotein D2 has been shown to interact with DDX20,[4] Small nuclear ribonucleoprotein D1,[5][6] Small nuclear ribonucleoprotein polypeptide F,[5] CDC5L[7] and SMN1.[8]


  1. ^ Lehmeier T, Raker V, Hermann H, Luhrmann R (January 1995). "cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction". Proc Natl Acad Sci U S A 91 (25): 12317–21. doi:10.1073/pnas.91.25.12317. PMC 45428. PMID 7527560. 
  2. ^ Lehmeier T, Foulaki K, Luhrmann R (January 1991). "Evidence for three distinct D proteins, which react differentially with anti-Sm autoantibodies, in the cores of the major snRNPs U1, U2, U4/U6 and U5". Nucleic Acids Res 18 (22): 6475–84. doi:10.1093/nar/18.22.6475. PMC 332598. PMID 1701240. 
  3. ^ a b "Entrez Gene: SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa". 
  4. ^ Charroux, B; Pellizzoni L; Perkinson R A; Shevchenko A; Mann M; Dreyfuss G (December 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". J. Cell Biol. (UNITED STATES) 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. ISSN 0021-9525. PMC 2168095. PMID 10601333. 
  5. ^ a b Fury, M G; Zhang W; Christodoulopoulos I; Zieve G W (November 1997). "Multiple protein: protein interactions between the snRNP common core proteins". Exp. Cell Res. (UNITED STATES) 237 (1): 63–9. doi:10.1006/excr.1997.3750. ISSN 0014-4827. PMID 9417867. 
  6. ^ Kambach, C; Walke S; Young R; Avis J M; de la Fortelle E; Raker V A; Lührmann R; Li J; Nagai K (February 1999). "Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs". Cell (UNITED STATES) 96 (3): 375–87. doi:10.1016/S0092-8674(00)80550-4. ISSN 0092-8674. PMID 10025403. 
  7. ^ Ajuh, P; Kuster B; Panov K; Zomerdijk J C; Mann M; Lamond A I (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. (ENGLAND) 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. ISSN 0261-4189. PMC 305846. PMID 11101529. 
  8. ^ Meister, G; Bühler D; Laggerbauer B; Zobawa M; Lottspeich F; Fischer U (August 2000). "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins". Hum. Mol. Genet. (ENGLAND) 9 (13): 1977–86. doi:10.1093/hmg/9.13.1977. ISSN 0964-6906. PMID 10942426. 

Further reading[edit]