Small nucleolar RNA SNORD64

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Small Nucleolar RNA SNORD64
RF00570.jpg
Predicted secondary structure and sequence conservation of SNORD64
Identifiers
Symbol SNORD64
Alt. Symbols snoHBII-13
Rfam RF00570
Other data
RNA type Gene; snRNA; snoRNA; C/D-box
Domain(s) Eukaryota
GO 0006396 0005730
SO 0000593

SNORD64 (also known as HBII-13) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifiying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

SNORD64 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1]

snoRNA HBII-13 is expressed mainly in the tissues of brain, but is also in the lungs, the kidneys and muscle;[2] however HBII-13 has no identified target RNA.[3] The HBII-13 gene is located in a 460 kb intron of the large paternally-expressed transcription unit (SNURF-SNRNP-UBE3A AS) along with several other snoRNAs HBII-436, HBII-437, HBII-438A/B and the clusters of HBII-85, HBII-52.[4] This host gene is an antisense transcript to maternally expressed UBE3A gene.

References[edit]

  1. ^ Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.  edit
  2. ^ Cavaillé, J. R. M.; Buiting, K.; Kiefmann, M.; Lalande, M.; Brannan, C. I.; Horsthemke, B.; Bachellerie, J. P.; Brosius, J. R.; Huttenhofer, A. (19 December 2000). "Identification of brain-specific and imprinted small nucleolar RNA genes exhibiting an unusual genomic organization". Proceedings of the National Academy of Sciences 97 (26): 14311–14316. doi:10.1073/pnas.250426397. PMC 18915. PMID 11106375.  edit
  3. ^ Lestrade, Laurent; Weber, Michel J. (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research 34 (Supplement 1: Database Issue): D158–D162. doi:10.1093/nar/gkj002. PMC 1347365. PMID 16381836. CiteSeerX: 10.1.1.105.7552.  edit
  4. ^ Runte, Maren; Hüttenhofer, Alexander; Gross, Stephanie; Kiefmann, Martin; Horsthemke, Bernhard; Buiting, Karin (2001). "The IC-SNURF-SNRPN transcript serves as a host for multiple small nucleolar RNA species and as an antisense RNA for UBE3A". Human Molecular Genetics 10 (23): 2687–2700. doi:10.1093/hmg/10.23.2687. PMID 11726556.  edit

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