Small nucleolar RNA snoR1
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| Small nucleolar RNA snoR1 | |
|---|---|
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| Predicted secondary structure and sequence conservation of snoR1 | |
| Identifiers | |
| Symbol | snoR1 |
| Rfam | RF00345 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; CD-box |
| Domain(s) | Eukaryota |
| GO | 0006396 0005730 |
| SO | 0000593 |
Small nucleolar RNA snoR1 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA snoR1 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs[1]. Plant snoRNA snoR1 was identified in a screen of Arabidopsis thaliana [2].
[edit] References
- ^ Galardi, S; Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (2002). "Purified Box C/D snoRNPs Are Able To Reproduce Site-Specific 2′-O-Methylation of Target RNA In Vitro". Mol Cell Biol 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=134041.
- ^ Barneche F, Gaspin C, Guyot R, Echeverría M (2001). "Identification of 66 box C/D snoRNAs in Arabidopsis thaliana: extensive gene duplications generated multiple isoforms predicting new ribosomal RNA 2'-O-methylation sites". J. Mol. Biol. 311 (1): 57–73. doi:10.1006/jmbi.2001.4851. PMID 11469857.
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