Smythesdale is a town in Victoria, Australia. The town is located on the Glenelg Highway in the Golden Plains Shire local government area, 19 kilometres (12 mi) west of Ballarat and 135 kilometres (84 mi) west of the state capital, Melbourne. At the 2006 census, Smythesdale had a population of 280.
The town was established during the Victorian Gold Rush, and the Post Office opened on 14 July 1854. The town was known as Smythe's Creek until 1864.
Facilities in the town include the Court House Hotel, a bluestone police lock up, constructed in 1869 and the old Court House, now home to the local historical society.
Smythesdale is the birthplace of Arthur Alfred Lynch, a polymath who was trained in engineering and medicine, wrote poetry, was a Member of the British Parliament and fought against the British in the Second Boer War. It was also home to women's rights activist, Lillias Margaret Skene.