snRNP70

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Small nuclear ribonucleoprotein 70kDa (U1)
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols SNRNP70 ; RNPU1Z; RPU1; SNRP70; Snp1; U1-70K; U170K; U1AP; U1RNP
External IDs OMIM180740 MGI98341 HomoloGene20672 GeneCards: SNRNP70 Gene
RNA expression pattern
PBB GE SNRP70 201221 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6625 20637
Ensembl ENSG00000104852 ENSMUSG00000063511
UniProt P08621 Q62376
RefSeq (mRNA) NM_001009820 NM_009224
RefSeq (protein) NP_003080 NP_033250
Location (UCSC) Chr 19:
49.59 – 49.61 Mb
Chr 7:
45.38 – 45.4 Mb
PubMed search [1] [2]

snRNP70 also known as U1 small nuclear ribonucleoprotein 70 kDa is a protein[1] that in humans is encoded by the SNRNP70 gene.[2][3] snRNP70 is a small nuclear ribonucleoprotein that associates with U1 spliceosomal RNA, forming part of the spliceosome.

Interactions[edit]

snRNP70 has been shown to interact with ASF/SF2,[4][5] SRPK1,[6][7] and ZRANB2.[8]

Role in autoimmunity[edit]

Antibodies towards snRNP70 are associated with mixed connective tissue disease.[9]


References[edit]

  1. ^ Spritz RA, Strunk K, Surowy CS, Hoch SO, Barton DE, Francke U (December 1987). "The human U1-70K snRNP protein: cDNA cloning, chromosomal localization, expression, alternative splicing and RNA-binding". Nucleic Acids Res. 15 (24): 10373–91. doi:10.1093/nar/15.24.10373. PMC 339950. PMID 2447561. 
  2. ^ "Entrez Gene: SNRP70 small nuclear ribonucleoprotein 70kDa polypeptide (RNP antigen)". 
  3. ^ Spritz RA, Strunk K, Surowy CS, Mohrenweiser HW (October 1990). "Human U1-70K ribonucleoprotein antigen gene: organization, nucleotide sequence, and mapping to locus 19q13.3". Genomics 8 (2): 371–9. doi:10.1016/0888-7543(90)90295-6. PMID 2147422. 
  4. ^ Xiao SH, Manley JL (November 1998). "Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2". EMBO J. 17 (21): 6359–67. doi:10.1093/emboj/17.21.6359. PMC 1170960. PMID 9799243. 
  5. ^ Cao W, Garcia-Blanco MA (August 1998). "A serine/arginine-rich domain in the human U1 70k protein is necessary and sufficient for ASF/SF2 binding". J. Biol. Chem. 273 (32): 20629–35. doi:10.1074/jbc.273.32.20629. PMID 9685421. 
  6. ^ Wang HY, Lin W, Dyck JA, Yeakley JM, Songyang Z, Cantley LC, Fu XD (February 1998). "SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells". J. Cell Biol. 140 (4): 737–50. doi:10.1083/jcb.140.4.737. PMC 2141757. PMID 9472028. 
  7. ^ Kamachi M, Le TM, Kim SJ, Geiger ME, Anderson P, Utz PJ (November 2002). "Human autoimmune sera as molecular probes for the identification of an autoantigen kinase signaling pathway". J. Exp. Med. 196 (9): 1213–25. doi:10.1084/jem.20021167. PMC 2194102. PMID 12417631. 
  8. ^ Adams DJ, van der Weyden L, Mayeda A, Stamm S, Morris BJ, Rasko JE (July 2001). "ZNF265--a novel spliceosomal protein able to induce alternative splicing". J. Cell Biol. 154 (1): 25–32. doi:10.1083/jcb.200010059. PMC 2196870. PMID 11448987. 
  9. ^ Sato, T; Fujii, T; Yokoyama, T; Fujita, Y; Imura, Y; Yukawa, N; Kawabata, D; Nojima, T; Ohmura, K; Usui, T; Mimori, T (Dec 2010). "Anti-U1 RNP antibodies in cerebrospinal fluid are associated with central neuropsychiatric manifestations in systemic lupus erythematosus and mixed connective tissue disease.". Arthritis and rheumatism 62 (12): 3730–40. doi:10.1002/art.27700. PMID 20722023. 

Further reading[edit]