Originally from Edo, he spent some time in Nagasaki, where he studied under the Chinese painter Song Ziyan, who was known as Sō Shigan in Japanese. The name Sō Shiseki is a art-name, derived from an imitation of his master's name.
Shiseki's bird and flower paintings and other works display the use of a combination of broad calligraphic brushstrokes for branches, tree trunks and rocks, ink wash and color for flower petals and leaves, and much finer brushstrokes for the fine details of feathers and flowers to produce a very detailed and lifelike, realistic depiction. Returning to Edo, Shiseki became a prominent representative and teacher of the Nagasaki school in that city, teaching Shiba Kōkan among others. He was close with such rangaku scholars as Hiraga Gennai and Sugita Genpaku, and expressed an interest in Western painting. He composed a number of books, and woodblock printed volumes of his artworks were produced as well.
- Sō Shiseki to ha (宋紫石とは, "Sō Shishiki is..."). Kotobank.jp. Accessed 1 September 2009.
- Morse, Anne Nishimura et al. (eds.) MFA Highlights: Arts of Japan. Boston: Museum of Fine Arts, 2008. p201.
- Bridge of dreams: the Mary Griggs Burke collection of Japanese art, a catalog from The Metropolitan Museum of Art Libraries (fully available online as PDF), which contains material on Sō Shiseki (see index)