In 2002, So So Def's distribution deal with Columbia Records ended. The following year, Dupri moved So So Def to Arista Records, where he was appointed president of Black Music. While many of So So Def's acts moved with the label to Arista, Bow Wow and Jagged Edge were forced to remain at Columbia, due to their contracts having been with that company primarily. In 2004, per the reconsolidation of labels caused by the merger of its former Sony Music parent and BMG, So So Def was shifted from Arista to its sister label, Zomba Label Group.
In 2005, Dupri was appointed Executive Vice President of Urban Music at Virgin Records, causing So So Def to move again, this time over to Virgin and EMI—resulting in the loss of acts such as Bone Crusher and the YoungBloodZ. So So Def, meanwhile, was able to retain J-Kwon and Anthony Hamilton, despite their still being signed to Zomba. In 2006, Dupri had a falling out with Virgin, resulting in his leaving his post at the company. Intermittent, he was appointed President of urban music at Universal Music Group'sIsland Records, resulting in So So Def once again making a move to UMG's The Island Def Jam Music Group.
In 2009, it was reported that Dupri had been terminated from his post at Island Records. Later in the same year, it was rumored that So So Def had moved back to Sony Music, where it reportedly operated under Zomba Label Group once more. In 2010, Mississippi-based independent label Malaco Records distributed So So Def's release of the Why Did I Get Married Too? soundtrack.
The code “SOSODEF” unlocks Jermaine Dupri as a player in the basketball video game NBA Live 2004.