Soai reaction

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Soai reaction is alkylation of pyrimidine-5-carbaldehyde by diisopropylzinc. The product pyrimidyl alcohol acts as an autocatalyst, and with low enantiomeric excess yield product with very high enantiomeric excess.[1]

The Japanese chemist Kenso Soai (1950–) discovered the reaction in 1995.[2]

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  1. ^ Chirality and Life: A Short Introduction to the Early Phases of Chemical. pp. 16–17. 
  2. ^ Shibata, Takanori; Morioka, Hiroshi; Hayase, Tadakatsu; Choji, Kaori; Soai, Kenso (1996). "Highly Enantioselective Catalytic Asymmetric Automultiplication of Chiral Pyrimidyl Alcohol". Journal of the American Chemical Society 118: 471. doi:10.1021/ja953066g. 

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