|This article needs additional citations for verification. (June 2013)|
|Jmol-3D images||Image 1|
|Molar mass||129.911 g/mol|
|Appearance||white or grayish powder|
|Density||1.87 g/cm 3|
|Solubility in water||soluble in water|
|Solubility||slightly soluble in alcohol|
|LD50||100 mg/kg (rat, oral)|
|Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)|
|(what is: / ?)|
Sodium arsenite refers to one of two compounds: sodium meta-arsenite (NaAsO2) or sodium ortho-arsenite (Na3AsO3). It is the sodium salt of arsenous acid. The solid consists of sodium cations, Na+, and catena-arsenite anions, [AsO2]n−
n, which are infinite -O-As(=O)- chains.
A mixture of sodium meta-arsenite and sodium ortho-arsenite is produced by dissolving arsenic trioxide in a solution of sodium carbonate or sodium hydroxide and boiling. Alternatively, it can be created by a controlled interaction of caustic soda with arsenic trioxide. AsO4 can be boiled with any alkali hydroxide to produce alkali arsenite.
Sodium Arsenite can be inhaled or absorbed through the skin. Along with its known carcinogenic and teratogenic effects, contact with the substance can yield symptoms such as skin irritation, burns,itching, thickened skin, rash, loss of pigment, poor appetite, a metallic or garlic taste, stomach pain, nausea, vomiting, diarrhea, convulsions, decreased blood pressure, and headache. Severe acute poisoning may lead to nervous system damage resulting in weakness, poor coordination, or “pins and needles” sensations, eventual paralysis, and death.
Pure arsenic is reported to be nontoxic. However since it is readily oxidized in air, and it is difficult to be sure no impurities are present, the element should be treated with caution. All measures of personal protective equipment must be utilized in order to protect oneself from effects.
Ironically, despite its carcinogenic effects, upregulation and inhibition of various enzymes in cancerous cells by sodium arsenite results in mitochondrial apoptosis, leading to remission. More treatments are proving effective with continued research of the toxin.
- Eagleton M. (2011). Concise Encyclopedia Chemistry. Walter de Gruyter. ISBN 3110114518.
- New Jersey Department of Health and Senior Services. Hazardous Substance Fact Sheet: Sodium Arsenite  (2013-05-01)
- Jing J, Zheng G, Liu M, Shen X, Zhao F, Wang J, Zhang J, Huang G, Dai P, Chen Y, Chen J, Luo W, ‘’et al.’’ (2012). "Changes in the synaptic structure of hippocampal neurons and impairment of spatial memory in a rat model caused by chronic arsenite exposure". Neurotoxicology 33 (5): 1230–8. doi:10.1016/j.neuro.2012.07.003. PMID 22824511.
- Science Lab: Chemicals & Laboratory Equipment. Material Safety Data Sheet Sodium arsenite, powder MSDS  (2013-05-01)
- Haynes W.M. (2012–2013). CRC Handbook of Chemistry and Physics, 93rd Ed. Taylor & Francis Group. ISBN 1439880492.
- Considine G.D. (2005). Van Nostrand’s Encylcopedia of Chemistry. 14th Ed. ISBN 0471615250.
- Bhagat L, Singh VP, Dawra RK, Saluja AK, ‘’et al.’’ (2008). "Sodium arsenite induces heat shock protein 70 expression and protects against secretagogue-induced trypsinogen and NF-kappaB activation". J Cell Physiol 215 (1): 37–46. doi:10.1002/jcp.21286. PMID 17941083.
- Ivanov VN, Hei TK, ‘’et al.’’ (2011). "Regulation of apoptosis in human melanoma and neuroblastoma cells by statins, sodium arsenite and TRAIL: a role of combined treatment versus monotherapy". Apoptosis. 16 (5): 1268–84. doi:10.1007/s10495-011-0649-2. PMID 21910007.